alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNAc-yl group (CHEBI:17785)

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ChEBI Name	α-D-Galp-(1→3)-β-D-Galp-(1→4)-D-GlcpNAc-yl group

ChEBI ID	CHEBI:17785

ChEBI ASCII Name	alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNAc-yl group

Definition	An N-acetyl-D-glucosaminyl group comprising one N-acetylated glucosamine and two galactose residues, linked as shown. A trisaccharide antigen found in all animals apart from Old World primates and humans, it is the main xenoantigen hampering the success of clinical xenotransplantation. Obtained formally by removing the hydroxy group from the hemiacetal function of the amino trisaccharide α-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-N-acetyl-D-glucosamine.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:60181, CHEBI:22376, CHEBI:22381, CHEBI:12312, CHEBI:59172, CHEBI:10237

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Formula

C20H34NO15

Net Charge

Average Mass

528.48170

Monoisotopic Mass

528.19284

SMILES

C1([C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O[C@@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)O)O)O)NC(=O)C)*

Roles Classification
Biological Role(s):	carbohydrate allergen Any carbohydrate, carbohydrate derivative or derived substituent group which causes the onset of an allergic reaction. xenoantigen An antigen that is found in more than one species. epitope The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.

ChEBI Ontology
Outgoing	α-D-Galp-(1→3)-β-D-Galp-(1→4)-D-GlcpNAc-yl group (CHEBI:17785) has role carbohydrate allergen (CHEBI:143231) α-D-Galp-(1→3)-β-D-Galp-(1→4)-D-GlcpNAc-yl group (CHEBI:17785) has role epitope (CHEBI:53000) α-D-Galp-(1→3)-β-D-Galp-(1→4)-D-GlcpNAc-yl group (CHEBI:17785) has role xenoantigen (CHEBI:132710) α-D-Galp-(1→3)-β-D-Galp-(1→4)-D-GlcpNAc-yl group (CHEBI:17785) is a N-acetyl-D-glucosaminyl groups (CHEBI:21524) α-D-Galp-(1→3)-β-D-Galp-(1→4)-D-GlcpNAc-yl group (CHEBI:17785) is substituent group from α-D-Gal-(1→3)-β-D-Gal-(1→4)-D-GlcNAc (CHEBI:18217)

Incoming	biotinylated α-gal (CHEBI:82651) has part α-D-Galp-(1→3)-β-D-Galp-(1→4)-D-GlcpNAc-yl group (CHEBI:17785) α-D-Galp-(1→3)-β-D-Galp-(1→4)-β-D-GlcpNAc-yl group (CHEBI:12308) is a α-D-Galp-(1→3)-β-D-Galp-(1→4)-D-GlcpNAc-yl group (CHEBI:17785)

IUPAC Names

α-D-galactopyranosyl-(1→3) β-D-galactopyranosyl-(1→4)-2-acetamido-2-deoxy-D-glucopyranosyl

α-D-galactopyranosyl-(1→3)-β-D-galactopyranosyl-(1→4)-2-acetamido-2-deoxy-D-glucopyranosyl

Synonyms	Sources
α-D-Gal(1→3)-β-D-Gal(1→4)-D-GlcNAc-yl group	ChEBI
α-D-Gal-(1→3)-β-D-Gal-(1→4)-D-GlcNHAc-R	ChEBI
α-D-galactopyranosyl-(1→3) β-D-galactopyranosyl-(1→4)-2-acetamido-2-deoxy-D-glucopyranosyl group	ChEBI
alpha-D-Galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R	KEGG COMPOUND
α-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-N-acetyl-D-glucosaminyl group	ChEBI
alpha-D-Galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R	KEGG COMPOUND
alpha-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl group	ChEBI
α-D-Galp-(1→3)-β-D-Galp-(1→4)-D-Glcp-NAc-yl group	ChEBI
α-D-Galp-(1→3)-β-D-Galp-(1→4)-D-GlcpNHAc-R	ChEBI
alpha-gal	ChEBI
α-Gal trisaccharide	ChEBI
α-Gal trisaccharide epitope	ChEBI
α-Gal3	ChEBI
α-galactosyl epitope	ChEBI
Gal(α1→3)-Gal(β1→4)-GlcNAc-R	ChEBI
Galα1-3Galβ1-4GlcNAc-	ChEBI
Galα1-3LacNAc-	ChEBI

Last Modified

12 March 2019