Services
Research
Training
Industry
About us
ChEBI
Examples:
iron*
,
InChI=1S/CH4O/c1-2/h2H,1H3
,
caffeine
Advanced
Home
Advanced Search
Browse
Documentation
Download
Tools
About ChEBI
Submit
Contact us
DiNA
Statistics
Entity of the Month
Periodic Table
Ontology
Train online
User Manual
Annotation Manual
Developer Manual
FAQ's
BiNChE
libChEBI
Web Services
ChEBI
> Main
CHEBI:131968 - tyrphostin B42
Main
ChEBI Ontology
Automatic Xrefs
Reactions
Pathways
Models
ChEBI Name
tyrphostin B42
ChEBI ID
CHEBI:131968
Definition
A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2
E
)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine.
Stars
This entity has been manually annotated by the ChEBI Team.
Submitter
Ceri
Supplier Information
Download
Molfile
XML
SDF
Find compounds which contain this structure
Find compounds which resemble this structure
Take structure to the Advanced Search
Formula
C17H14N2O3
Net Charge
0
Average Mass
294.305
Monoisotopic Mass
294.10044
InChI
InChI=1S/C17H14N2O3/c18-
10-
14(8-
13-
6-
7-
15(20)
16(21)
9-
13)
17(22)
19-
11-
12-
4-
2-
1-
3-
5-
12/h1-
9,20-
21H,11H2,(H,19,22)
/b14-
8+
InChIKey
TUCIOBMMDDOEMM-RIYZIHGNSA-N
SMILES
C=1(C=CC(=CC1O)/C=C(/C(NCC=2C=CC=CC2)=O)\C#N)O
Roles Classification
Chemical Role
(s):
antioxidant
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
Biological Role
(s):
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2).
STAT3 inhibitor
An inhibitor of signal transducer and activator of transcription 3 (STAT3)
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application
(s):
anti-inflammatory agent
Any compound that has anti-inflammatory effects.
geroprotector
Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
tyrphostin B42 (
CHEBI:131968
)
has role
anti-inflammatory agent (
CHEBI:67079
)
tyrphostin B42 (
CHEBI:131968
)
has role
antioxidant (
CHEBI:22586
)
tyrphostin B42 (
CHEBI:131968
)
has role
apoptosis inducer (
CHEBI:68495
)
tyrphostin B42 (
CHEBI:131968
)
has role
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (
CHEBI:76617
)
tyrphostin B42 (
CHEBI:131968
)
has role
geroprotector (
CHEBI:176497
)
tyrphostin B42 (
CHEBI:131968
)
has role
STAT3 inhibitor (
CHEBI:87183
)
tyrphostin B42 (
CHEBI:131968
)
is a
catechols (
CHEBI:33566
)
tyrphostin B42 (
CHEBI:131968
)
is a
enamide (
CHEBI:51751
)
tyrphostin B42 (
CHEBI:131968
)
is a
monocarboxylic acid amide (
CHEBI:29347
)
tyrphostin B42 (
CHEBI:131968
)
is a
nitrile (
CHEBI:18379
)
tyrphostin B42 (
CHEBI:131968
)
is a
secondary carboxamide (
CHEBI:140325
)
IUPAC Name
(2
E
)-
N
-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
Synonyms
Sources
AG 490
SUBMITTER
AG-490
SUBMITTER
AG490
SUBMITTER
tyrphostin AG-490
ChemIDplus
Manual Xref
Database
LSM-42880
LINCS
View more database links
Registry Numbers
Types
Sources
133550-30-8
CAS Registry Number
ChemIDplus
4323263
Reaxys Registry Number
Reaxys
Citations
Types
Sources
10929036
PubMed citation
Europe PMC
22363408
PubMed citation
Europe PMC
26190257
PubMed citation
Europe PMC
26438799
PubMed citation
Europe PMC
26487394
PubMed citation
Europe PMC
26750536
PubMed citation
Europe PMC
26919242
PubMed citation
Europe PMC
27011172
PubMed citation
Europe PMC
27044832
PubMed citation
Europe PMC
27101310
PubMed citation
Europe PMC
27107220
PubMed citation
Europe PMC
27274711
PubMed citation
Europe PMC
Last Modified
27 October 2021