dynasore (CHEBI:132754)

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ChEBI Name	dynasore

ChEBI ID	CHEBI:132754

Definition	A carbohydrazide resulting from the formal condensation of the hydrazone moiety of 3,4-dihydroxybenzaldehyde hydrazone with the carboxy group of 3-hydroxy-2-naphthoic acid. It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity of dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Sabrina Toro

Supplier Information

Download	Molfile XML SDF

Formula

C18H14N2O4

Net Charge

Average Mass

322.315

Monoisotopic Mass

322.09536

InChI

InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+

InChIKey

SYNDQCRDGGCQRZ-VXLYETTFSA-N

SMILES

C=1C2=C(C=CC1)C=C(C(=C2)C(N/N=C/C=3C=C(C(=CC3)O)O)=O)O

Roles Classification
Biological Role(s):	EC 3.6.5.5 (dynamin GTPase) inhibitor An EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitor that interferes with the action of dynamin GTPase (EC 3.6.5.5).

ChEBI Ontology
Outgoing	dynasore (CHEBI:132754) has functional parent 3-Hydroxy-2-naphthoate (CHEBI:80383) dynasore (CHEBI:132754) has role EC 3.6.5.5 (dynamin GTPase) inhibitor (CHEBI:132772) dynasore (CHEBI:132754) is a catechols (CHEBI:33566) dynasore (CHEBI:132754) is a hydrazide (CHEBI:35362) dynasore (CHEBI:132754) is a hydrazone (CHEBI:38532) dynasore (CHEBI:132754) is a naphthols (CHEBI:25392)

IUPAC Name

N'-[(E)-(3,4-dihydroxyphenyl)methylene]-3-hydroxy-2-naphthohydrazide

Synonyms	Sources
3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide	SUBMITTER
Dynamin Inhibitor I	SUBMITTER

Last Modified

20 July 2016