CHEBI:132781 - HA15

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ChEBI Name HA15
ChEBI ID CHEBI:132781
Definition A sulfonamide resulting from the formal condensation of the sulfonic acid group of 5-(dimethylamino)naphthalene-1-sulfonic acid with the aniline nitrogen of 3-(2-acetamido-1,3-thiazol-4-yl)aniline. It has been reported that by triggering an endoplasmic reticulum (ER) stress response, HA15 can reduce the viability of melanoma cells without being toxic to normal cells.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Margaret Duesbury
Supplier Information
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Formula C23H22N4O3S2
Net Charge 0
Average Mass 466.579
Monoisotopic Mass 466.11333
InChI InChI=1S/C23H22N4O3S2/c1-15(28)24-23-25-20(14-31-23)16-7-4-8-17(13-16)26-32(29,30)22-12-6-9-18-19(22)10-5-11-21(18)27(2)3/h4-14,26H,1-3H3,(H,24,25,28)
InChIKey LBSMEKVVMYSTIH-UHFFFAOYSA-N
SMILES C12=CC=CC(=C1C=CC=C2S(NC=3C=C(C=CC3)C4=CSC(=N4)NC(=O)C)(=O)=O)N(C)C
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing HA15 (CHEBI:132781) has role antineoplastic agent (CHEBI:35610)
HA15 (CHEBI:132781) is a 1,3-thiazoles (CHEBI:38418)
HA15 (CHEBI:132781) is a acetamides (CHEBI:22160)
HA15 (CHEBI:132781) is a aminonaphthalene (CHEBI:38034)
HA15 (CHEBI:132781) is a biaryl (CHEBI:64459)
HA15 (CHEBI:132781) is a sulfonamide (CHEBI:35358)
HA15 (CHEBI:132781) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
N-{4-[3-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)phenyl]-1,3-thiazol-2-yl}acetamide
Synonyms Sources
HA-15 ChEBI
N-(4-{3-[5-(dimethylamino)naphthalene-1-sulfonamido]phenyl}thiazol-2-yl)acetamide ChEBI
Registry Number Type Source
26947881 Reaxys Registry Number Reaxys
Citation Waiting for Citations Type Source
27238082 PubMed citation SUBMITTER
Last Modified
21 July 2016