quininib (CHEBI:133170)

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ChEBI Name	quininib

ChEBI ID	CHEBI:133170

Definition	A styrylquinoline that is trans-2-styrylquinoline in which the the phenyl group has been substituted at position 2 by a hydroxy group. It is an anti-angiogenic compound that exerts a dose-dependent antagonism of the cysteinyl leukotriene pathway, preferentially antagonising cysteinyl leukotriene receptor 1. The major species at pH 7.3

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Ceri

Supplier Information

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Formula

C17H13NO

Net Charge

Average Mass

247.292

Monoisotopic Mass

247.09971

InChI

InChI=1S/C17H13NO/c19-17-8-4-2-6-14(17)10-12-15-11-9-13-5-1-3-7-16(13)18-15/h1-12,19H/b12-10+

InChIKey

NXNDEWNGCMCWMA-ZRDIBKRKSA-N

SMILES

C1=2C(C=CC=C1)=NC(=CC2)/C=C/C=3C(=CC=CC3)O

Roles Classification
Application(s):	angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.

ChEBI Ontology
Outgoing	quininib (CHEBI:133170) has functional parent trans-2-styrylquinoline (CHEBI:51072) quininib (CHEBI:133170) has role angiogenesis inhibitor (CHEBI:48422) quininib (CHEBI:133170) is a phenols (CHEBI:33853) quininib (CHEBI:133170) is a styrylquinoline (CHEBI:26800) quininib (CHEBI:133170) is conjugate base of quininib(1+) (CHEBI:133233)

Incoming	quininib(1+) (CHEBI:133233) is conjugate acid of quininib (CHEBI:133170)

IUPAC Name

2-[(E)-2-(quinolin-2-yl)vinyl]phenol

Registry Number	Type	Source
1379458-56-6	CAS Registry Number	SUBMITTER

Citation	Type	Source
26846851	PubMed citation	Europe PMC

Last Modified

11 September 2016