clofedanol (CHEBI:135207)

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ChEBI Name	clofedanol

ChEBI ID	CHEBI:135207

Definition	A diarylmethane that is 2-chlorophenyl(phenyl)methane substituted on the methane carbon by a 2-(dimethylamino)ethyl group. Used in the treatment of dry cough, it suppresses the cough reflex by a direct effect on the cough centre in the medulla of the brain.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C17H20ClNO

Net Charge

Average Mass

289.800

Monoisotopic Mass

289.12334

InChI

InChI=1S/C17H20ClNO/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18/h3-11,20H,12-13H2,1-2H3

InChIKey

WRCHFMBCVFFYEQ-UHFFFAOYSA-N

SMILES

C(CCN(C)C)(O)(C1=C(Cl)C=CC=C1)C2=CC=CC=C2

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Application(s):	antitussive An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.

ChEBI Ontology
Outgoing	clofedanol (CHEBI:135207) has role antitussive (CHEBI:51177) clofedanol (CHEBI:135207) is a diarylmethane (CHEBI:51614) clofedanol (CHEBI:135207) is a tertiary amino compound (CHEBI:50996) clofedanol (CHEBI:135207) is conjugate base of clofedanol(1+) (CHEBI:187895)

Incoming	clofedanol(1+) (CHEBI:187895) is conjugate acid of clofedanol (CHEBI:135207)

IUPAC Name

1-(2-chlorophenyl)-3-(dimethylamino)-1-phenylpropan-1-ol

Synonym	Source
chlophedianol	DrugCentral

Last Modified

14 June 2018