CHEBI:139496 - titanium(IV) isopropoxide

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ChEBI Name titanium(IV) isopropoxide ChEBI ID CHEBI:139496 ChEBI ASCII Name titanium(IV) isopropoxide Definition A titanium coordination entity consisting of a titanium(IV) cation with four propan-2-olate anions as counterions. Stars This entity has been manually annotated by the ChEBI Team. Supplier Information ChemicalBook:CB5163816, eMolecules:496010 Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Wikipedia License Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is taken orally or intravenously for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, eczema, and in organ transplants to prevent rejection. It is also used as eye drops for keratoconjunctivitis sicca (dry eyes). Common side effects include high blood pressure, headache, kidney problems, increased hair growth, and vomiting. Other severe side effects include an increased risk of infection, liver problems, and an increased risk of lymphoma. Blood levels of the medication should be checked to decrease the risk of side effects. Use during pregnancy may result in preterm birth; however, ciclosporin does not appear to cause birth defects. Ciclosporin is believed to work by decreasing the function of lymphocytes. It does this by forming a complex with cyclophilin to block the phosphatase activity of calcineurin, which in turn decreases the production of inflammatory cytokines by T-lymphocytes. Ciclosporin was isolated in 1971 from the fungus Tolypocladium inflatum and came into medical use in 1983. It is on the World Health Organization's List of Essential Medicines. In 2022, it was the 185th most commonly prescribed medication in the United States, with more than 2 million prescriptions. It is available as a generic medication. Read full article at Wikipedia Formula C12H28O4Ti Net Charge 0 Average Mass 284.216 Monoisotopic Mass 284.14670 InChI InChI=1S/4C3H7O.Ti/c4*1-3(2)4;/h4*3H,1-2H3;/q4*-1;+4 InChIKey VXUYXOFXAQZZMF-UHFFFAOYSA-N SMILES [Ti+4].CC([O-])C.CC([O-])C.CC([O-])C.CC([O-])C ChEBI Ontology Outgoing titanium(IV) isopropoxide (CHEBI:139496) is a titanium coordination entity (CHEBI:51004) IUPAC Name titanium(4+) tetrapropan-2-olate Synonyms Sources 2-propanol, titanium(4+) salt (4:1) ChEBI tetraisopropanolatotitanium ChemIDplus tetraisopropyl orthotitanate ChemIDplus tetraisopropyl titanate ChemIDplus tetrakis(isopropoxy)titanium ChemIDplus titanium isopropoxide ChemIDplus titanium isopropylate ChemIDplus titanium tetraisopropylate ChemIDplus TTIP ChEBI Manual Xref Database Titanium_isopropoxide Wikipedia View more database links Registry Numbers Types Sources 10775048 Reaxys Registry Number Reaxys 3679474 Reaxys Registry Number Reaxys 546-68-9 CAS Registry Number ChemIDplus Citation Type Source 29079364 PubMed citation Europe PMC Last Modified 19 January 2018