InChI=1S/C15H12O6/c16-9-3-1-8(2-4-9)15(20)7-12(19)14-11(18)5-10(17)6-13(14)21-15/h1-6,16-18,20H,7H2 |
NFENYLPEYDNIMO-UHFFFAOYSA-N |
O1C2=C(C(CC1(C3=CC=C(C=C3)O)O)=O)C(=CC(=C2)O)O |
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Cornus kousa
(NCBI:txid28501)
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Found in
stem
(BTO:0001300).
See:
PubMed
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Abies sp.ctabilis
(NCBI:txid342581)
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Found in
aerial part
(BTO:0001658).
See:
PubMed
|
plant metabolite
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
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View more via ChEBI Ontology
Outgoing
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2,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
(CHEBI:142230)
has role
plant metabolite
(CHEBI:76924)
2,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
(CHEBI:142230)
is a
2-hydroxyflavanones
(CHEBI:141992)
2,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
(CHEBI:142230)
is a
tetrahydroxyflavanone
(CHEBI:38742)
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Incoming
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(2R)-2-hydroxynaringenin
(CHEBI:142229)
is a
2,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
(CHEBI:142230)
(2S)-2-hydroxynaringenin
(CHEBI:141994)
is a
2,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
(CHEBI:142230)
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2,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
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2,3-dihydro-2,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
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HMDB
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2,4',5,7-tetrahydroxyflavanone
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HMDB
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2,5,7-trihydroxy-2-(4-hydroxyphenyl)-3H-1-benzopyran-4-one
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HMDB
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2,5,7-trihydroxy-2-(4-hydroxyphenyl)-3H-chromen-4-one
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ChEBI
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2-hydroxynaringenin
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ChEBI
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7254315
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Reaxys Registry Number
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Reaxys
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Han XJ, Wu YF, Gao S, Yu HN, Xu RX, Lou HX, Cheng AX (2014) Functional characterization of a Plagiochasma appendiculatum flavone synthase I showing flavanone 2-hydroxylase activity. FEBS letters 588, 2307-2314 [PubMed:24859082] [show Abstract] FNS I is a 2-oxoglutarate dependent dioxygenase (2-ODD) found mainly in species of the Apiaceae family. Here, an FNS I cDNA sequence was isolated from the liverwort Plagiochasma appendiculatum (Aytoniaceae) and characterized. The recombinant protein exhibited high FNS I activity catalyzing the conversion of naringenin to apigenin and 2-hydroxynaringenin. The critical residue for flavanone-2-hydroxylation activity was Tyr240, as identified from homology modeling and site-directed mutagenesis. The recombinant protein also showed some flavonol synthase activity, as it can convert dihydrokaempferol to kaempferol. When the Leu311 residue was mutated to Phe, the enzyme's capacity to convert dihydrokaempferol to kaempferol was substantially increased. PaFNS I represents a 2-ODD in which a hydrophobic π-stacking interaction between the key residue and the naringenin A-ring determines 2-hydroxyflavanone formation. |
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