5-(2-chlorophenyl)-7-(dihydroxyamino)-1,3-dihydro-1,4-benzodiazepin-2-one (CHEBI:143343)

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This entity has been annotated by a third party. If you would like more information added to this entry, please contact ChEBI via email or GitHub.

ChEBI Name	5-(2-chlorophenyl)-7-(dihydroxyamino)-1,3-dihydro-1,4-benzodiazepin-2-one

ChEBI ID	CHEBI:143343

Stars	This entity has been manually annotated by a third party.

Submitter	Mark Williams

Supplier Information	ChemicalBook:CB1278653, eMolecules:494789, ZINC000000409269

Download	Molfile XML SDF

Formula

C15H12ClN3O3

Net Charge

Average Mass

317.728

Monoisotopic Mass

317.057

InChI

InChI=1S/C15H12ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7,21-22H,8H2,(H,18,20)

InChIKey

QKPRGUMFCHDCOK-UHFFFAOYSA-N

SMILES

ClC1=C(C2=NCC(=O)NC3=C2C=C(N(O)O)C=C3)C=CC=C1

Roles Classification
Biological Role(s):	GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. (via benzodiazepine )

Application(s):	GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. (via benzodiazepine )

ChEBI Ontology
Outgoing	5-(2-chlorophenyl)-7-(dihydroxyamino)-1,3-dihydro-1,4-benzodiazepin-2-one (CHEBI:143343) is a 1,4-benzodiazepinone (CHEBI:35500) 5-(2-chlorophenyl)-7-(dihydroxyamino)-1,3-dihydro-1,4-benzodiazepin-2-one (CHEBI:143343) is a monochlorobenzenes (CHEBI:83403)