CHEBI:143428 - N-demethylmirtazapine

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ChEBI Name N-demethylmirtazapine
ChEBI ID CHEBI:143428
ChEBI ASCII Name N-demethylmirtazapine
Definition A benzazepine metabolite resulting from demethylation of the antidpressant, mirtazapine.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Mark Williams
Supplier Information
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Formula C16H17N3
Net Charge 0
Average Mass 251.333
Monoisotopic Mass 251.14225
InChI InChI=1S/C16H17N3/c1-2-6-14-12(4-1)10-13-5-3-7-18-16(13)19-9-8-17-11-15(14)19/h1-7,15,17H,8-11H2
InChIKey FGLAMNFOHWVQOH-UHFFFAOYSA-N
SMILES N1=C2N3C(C=4C=CC=CC4CC2=CC=C1)CNCC3
Roles Classification
Biological Role(s): human xenobiotic metabolite
Any human metabolite produced by metabolism of a xenobiotic compound in humans.
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Application(s): alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
anxiolytic drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
antidepressant
Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
(via tetracyclic antidepressant )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing N-demethylmirtazapine (CHEBI:143428) has role α-adrenergic antagonist (CHEBI:37890)
N-demethylmirtazapine (CHEBI:143428) has role anxiolytic drug (CHEBI:35474)
N-demethylmirtazapine (CHEBI:143428) has role H1-receptor antagonist (CHEBI:37955)
N-demethylmirtazapine (CHEBI:143428) has role histamine antagonist (CHEBI:37956)
N-demethylmirtazapine (CHEBI:143428) has role human xenobiotic metabolite (CHEBI:76967)
N-demethylmirtazapine (CHEBI:143428) has role serotonergic antagonist (CHEBI:48279)
N-demethylmirtazapine (CHEBI:143428) is a benzazepine (CHEBI:35676)
N-demethylmirtazapine (CHEBI:143428) is a tetracyclic antidepressant (CHEBI:50940)
IUPAC Name
1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Synonyms Sources
demethylmirtazapine ChEBI
desmethyl mirtazapine ChemIDplus
desmethylmirtazapine ChemIDplus
N-demethylmirtazapine ChemIDplus
N-desmethylmirtazapine ChemIDplus
normirtazapine ChemIDplus
ORG-3838 ChemIDplus
Manual Xref Database
HMDB0060956 HMDB
View more database links
Registry Numbers Types Sources
3976057 Beilstein Registry Number Beilstein
61337-68-6 CAS Registry Number ChemIDplus
61337-68-6 CAS Registry Number NIST Chemistry WebBook
Citations Waiting for Citations Types Sources
14749554 PubMed citation Europe PMC
15257065 PubMed citation Europe PMC
15532581 PubMed citation Europe PMC
16051454 PubMed citation Europe PMC
19071885 PubMed citation Europe PMC
21646053 PubMed citation Europe PMC
25150039 PubMed citation Europe PMC
25276185 PubMed citation Europe PMC
Last Modified
03 June 2019