CHEBI:156321 - diazepinomicin

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This entity has been annotated by a third party. If you would like more information added to this entry, please contact ChEBI via email or GitHub.
ChEBI Name diazepinomicin
ChEBI ID CHEBI:156321
Definition A dibenzodiazepine with a farnesyl sidechain synthesized by Micromonospora sp.. It has a potent activity against a broad spectrum of tumor cell lines.
Stars This entity has been manually annotated by a third party.
Submitter Martin Larralde
Supplier Information
Download Molfile XML SDF
Formula C28H34N2O4
Net Charge 0
Average Mass 462.590
Monoisotopic Mass 462.25186
InChI InChI=1S/C28H34N2O4/c1-18(2)8-5-9-19(3)10-6-11-20(4)14-15-30-23-16-21(31)17-25(33)27(23)29-26-22(28(30)34)12-7-13-24(26)32/h7-8,10,12-14,16-17,29,31-33H,5-6,9,11,15H2,1-4H3/b19-10+,20-14+
InChIKey SALVHVNECODMJP-GNUCVDFRSA-N
SMILES CC(C)=CCC\C(\C)=C(\CC/C(/C)=C(\[H])/CN1C=2C=C(C=C(C2NC3=C(C=CC=C3O)C1=O)O)O)/[H]
Metabolite of Species Details
Micromonospora sp. RV115 (NCBI:txid1448265) See: PubMed
Micromonospora sp. (NCBI:txid1876) of strain DJ115 See: PubMed
Roles Classification
Chemical Role(s): antioxidant
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): cathepsin L (EC 3.4.22.15) inhibitor
An EC 3.4.22.* (cysteine endopeptidase) inhibitor which interferes with the action of cathepsin L (EC 3.4.22.15).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing diazepinomicin (CHEBI:156321) has part 2-trans,6-trans-farnesyl group (CHEBI:36535)
diazepinomicin (CHEBI:156321) has role antineoplastic agent (CHEBI:35610)
diazepinomicin (CHEBI:156321) has role antioxidant (CHEBI:22586)
diazepinomicin (CHEBI:156321) has role cathepsin L (EC 3.4.22.15) inhibitor (CHEBI:70821)
diazepinomicin (CHEBI:156321) is a dibenzodiazepine (CHEBI:64051)
diazepinomicin (CHEBI:156321) is a farnesane sesquiterpenoid (CHEBI:36757)
diazepinomicin (CHEBI:156321) is a olefinic compound (CHEBI:78840)
diazepinomicin (CHEBI:156321) is a secondary amine (CHEBI:32863)
diazepinomicin (CHEBI:156321) is a triol (CHEBI:27136)
Synonym Source
1,3,10-trihydroxy-5-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]-11H-benzo[b][1,4]benzodiazepin-6-one SUBMITTER
Manual Xref Database
DB12420 DrugBank accession
View more database links
Registry Number Type Source
733035-26-2 CAS Registry Number SUBMITTER
Citations Waiting for Citations Types Sources
15332871 PubMed citation SUBMITTER
23170078 PubMed citation SUBMITTER