CHEBI:16134 - ammonia

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ChEBI Name ammonia
ChEBI ID CHEBI:16134
Definition An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:44284, CHEBI:44269, CHEBI:44404, CHEBI:13405, CHEBI:13406, CHEBI:13407, CHEBI:13771, CHEBI:7434, CHEBI:22533
Supplier Information ChemicalBook:CB1191893, ChemicalBook:CB9854275, eMolecules:477343
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Ammonia is an inorganic chemical compound of nitrogen and hydrogen with the formula NH3. A stable binary hydride and the simplest pnictogen hydride, ammonia is a colourless gas with a distinctive pungent smell. Biologically, it is a common nitrogenous waste, and it contributes significantly to the nutritional needs of terrestrial organisms by serving as a precursor to fertilisers. Around 70% of ammonia produced industrially is used to make fertilisers in various forms and composition, such as urea and diammonium phosphate. Ammonia in pure form is also applied directly into the soil. Ammonia, either directly or indirectly, is also a building block for the synthesis of many chemicals. Ammonia occurs in nature and has been detected in the interstellar medium. In many countries, it is classified as an extremely hazardous substance. Ammonia is produced biologically in a process called nitrogen fixation, but even more is generated industrially by the Haber process. The process helped revolutionize agriculture by providing cheap fertilizers. The global industrial production of ammonia in 2021 was 235 million tonnes. Industrial ammonia is transported by road in tankers, by rail in tank wagons, by sea in gas carriers, or in cylinders. Ammonia boils at −33.34 °C (−28.012 °F) at a pressure of one atmosphere, but the liquid can often be handled in the laboratory without external cooling. Household ammonia or ammonium hydroxide is a solution of ammonia in water.
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Formula H3N
Net Charge 0
Average Mass 17.03056
Monoisotopic Mass 17.02655
InChI InChI=1S/H3N/h1H3
InChIKey QGZKDVFQNNGYKY-UHFFFAOYSA-N
SMILES [H]N([H])[H]
Metabolite of Species Details
Mus musculus (NCBI:txid10090) Source: BioModels - MODEL1507180067 See: PubMed
Roles Classification
Chemical Role(s): nucleophilic reagent
A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons.
NMR chemical shift reference compound
Any compound that produces a peak used as reference frequency in the delta chemical shift scale.
Biological Role(s): EC 3.5.1.4 (amidase) inhibitor
An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4).
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
neurotoxin
A poison that interferes with the functions of the nervous system.
Application(s): refrigerant
A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a "R" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure.
nucleophilic reagent
A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons.
NMR chemical shift reference compound
Any compound that produces a peak used as reference frequency in the delta chemical shift scale.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing ammonia (CHEBI:16134) has role EC 3.5.1.4 (amidase) inhibitor (CHEBI:77941)
ammonia (CHEBI:16134) has role metabolite (CHEBI:25212)
ammonia (CHEBI:16134) has role mouse metabolite (CHEBI:75771)
ammonia (CHEBI:16134) has role neurotoxin (CHEBI:50910)
ammonia (CHEBI:16134) has role NMR chemical shift reference compound (CHEBI:228364)
ammonia (CHEBI:16134) has role nucleophilic reagent (CHEBI:59740)
ammonia (CHEBI:16134) has role refrigerant (CHEBI:78433)
ammonia (CHEBI:16134) is a azane (CHEBI:35107)
ammonia (CHEBI:16134) is a gas molecular entity (CHEBI:138675)
ammonia (CHEBI:16134) is a mononuclear parent hydride (CHEBI:37176)
ammonia (CHEBI:16134) is conjugate acid of azanide (CHEBI:29337)
ammonia (CHEBI:16134) is conjugate base of ammonium (CHEBI:28938)
Incoming hexamethyldisilazane (CHEBI:85068) has parent hydride ammonia (CHEBI:16134)
hydroxylamine (CHEBI:15429) has parent hydride ammonia (CHEBI:16134)
organic amino compound (CHEBI:50047) has parent hydride ammonia (CHEBI:16134)
ammonium (CHEBI:28938) is conjugate acid of ammonia (CHEBI:16134)
azanide (CHEBI:29337) is conjugate base of ammonia (CHEBI:16134)
azanediyl group (CHEBI:29343) is substituent group from ammonia (CHEBI:16134)
azanetriyl group (CHEBI:30228) is substituent group from ammonia (CHEBI:16134)
imino group (CHEBI:29342) is substituent group from ammonia (CHEBI:16134)
primary amino group (CHEBI:46882) is substituent group from ammonia (CHEBI:16134)
IUPAC Names
ammonia
azane
Synonyms Sources
[NH3] MolBase
Ammonia KEGG COMPOUND
AMMONIA PDBeChem
ammoniac ChEBI
Ammoniak ChemIDplus
amoníaco ChEBI
NH3 KEGG COMPOUND
NH3 IUPAC
R-717 ChEBI
spirit of hartshorn ChemIDplus
Manual Xrefs Databases
4625 DrugCentral
930 MolBase
Ammonia Wikipedia
AMMONIA MetaCyc
C00007267 KNApSAcK
C00014 KEGG COMPOUND
D02916 KEGG DRUG
HMDB0000051 HMDB
NH3 PDBeChem
View more database links
Registry Numbers Types Sources
3587154 Reaxys Registry Number Reaxys
7664-41-7 CAS Registry Number KEGG COMPOUND
7664-41-7 CAS Registry Number NIST Chemistry WebBook
7664-41-7 CAS Registry Number ChemIDplus
79 Gmelin Registry Number Gmelin
Citations
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More actors in ammonia absorption by the thick ascending limb.
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Banerjee S, Siciliano SD (2012)
Factors driving potential ammonia oxidation in Canadian arctic ecosystems: does spatial scale matter?
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Procházka J, Dolejš P, Máca J, Dohányos M (2012)
Stability and inhibition of anaerobic processes caused by insufficiency or excess of ammonia nitrogen.
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Zeng Y, De Guardia A, Ziebal C, De Macedo FJ, Dabert P (2012)
Nitrification and microbiological evolution during aerobic treatment of municipal solid wastes.
Bioresource technology 110, 144-152 [PubMed:22342082]
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Imran M, Shah Y, Nundlall S, Roberts NB, Howse M (2012)
Is blood ammonia influenced by kidney function? A prospective study.
Clinical biochemistry 45, 363-365 [PubMed:22240068]
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Levičnik-Höfferle S, Nicol GW, Ausec L, Mandić-Mulec I, Prosser JI (2012)
Stimulation of thaumarchaeal ammonia oxidation by ammonia derived from organic nitrogen but not added inorganic nitrogen.
FEMS microbiology ecology 80, 114-123 [PubMed:22150211]
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Sher Y, Baram S, Dahan O, Ronen Z, Nejidat A (2012)
Ammonia transformations and abundance of ammonia oxidizers in a clay soil underlying a manure pond.
FEMS microbiology ecology 81, 145-155 [PubMed:22385337]
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Zhang L, Lee YW, Jahng D (2012)
Ammonia stripping for enhanced biomethanization of piggery wastewater.
Journal of hazardous materials 199-200, 36-42 [PubMed:22130175]
[show Abstract]
Sun H, Lü K, Minter EJ, Chen Y, Yang Z, Montagnes DJ (2012)
Combined effects of ammonia and microcystin on survival, growth, antioxidant responses, and lipid peroxidation of bighead carp Hypophthalmythys nobilis larvae.
Journal of hazardous materials 221-222, 213-219 [PubMed:22560242]
[show Abstract]
Weihrauch D, Donini A, O'Donnell MJ (2012)
Ammonia transport by terrestrial and aquatic insects.
Journal of insect physiology 58, 473-487 [PubMed:22100291]
[show Abstract]
Rivera-Mancía S, Ríos C, Montes S (2012)
Manganese and ammonia interactions in the brain of cirrhotic rats: effects on brain ammonia metabolism.
Neurochemical research 37, 1074-1084 [PubMed:22290316]
[show Abstract]
Bankura A, Chandra A (2012)
A first principles molecular dynamics study of the solvation structure and migration kinetics of an excess proton and a hydroxide ion in binary water-ammonia mixtures.
The Journal of chemical physics 136, 114509 [PubMed:22443779]
[show Abstract]
Byrne N, Strous M, Crépeau V, Kartal B, Birrien JL, Schmid M, Lesongeur F, Schouten S, Jaeschke A, Jetten M, Prieur D, Godfroy A (2009)
Presence and activity of anaerobic ammonium-oxidizing bacteria at deep-sea hydrothermal vents.
The ISME journal 3, 117-123 [PubMed:18670398]
[show Abstract]
Castrillo JI, Zeef LA, Hoyle DC, Zhang N, Hayes A, Gardner DC, Cornell MJ, Petty J, Hakes L, Wardleworth L, Rash B, Brown M, Dunn WB, Broadhurst D, O'Donoghue K, Hester SS, Dunkley TP, Hart SR, Swainston N, Li P, Gaskell SJ, Paton NW, Lilley KS, Kell DB, Oliver SG (2007)
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Javed MT, Irfan N, Gibbs BM (2007)
Control of combustion-generated nitrogen oxides by selective non-catalytic reduction.
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[show Abstract]
Chiang CT, Freindorf M, Furlani T, DeLeon RL, Richard JP, Garvey JF (2007)
Enhancement of a Lewis acid-base interaction via solvation: ammonia molecules and the benzene radical cation.
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[show Abstract]
Cui R, Jahng D (2006)
Enhanced methane production from anaerobic digestion of disintegrated and deproteinized excess sludge.
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Banks HD (2006)
The profound effect of fluorine substitution on the reactivity and regioselectivity of nucleophilic substitution reactions of strained heterocycles. A study of aziridine and its derivatives.
The Journal of organic chemistry 71, 8089-8097 [PubMed:17025297]
[show Abstract]
Fang CH, Chiang KA, Hung CH, Chang K, Ke SC, Chu HA (2005)
Effects of ethylene glycol and methanol on ammonia-induced structural changes of the oxygen-evolving complex in photosystem II.
Biochemistry 44, 9758-9765 [PubMed:16008360]
[show Abstract]
Calimsiz S, Lipton MA (2005)
Synthesis of N-Fmoc-(2S,3S,4R)-3,4-dimethylglutamine: An application of lanthanide-catalyzed transamidation.
The Journal of organic chemistry 70, 6218-6221 [PubMed:16050680]
[show Abstract]
Hanigan MD, Crompton LA, Reynolds CK, Wray-Cahen D, Lomax MA, France J (2004)
An integrative model of amino acid metabolism in the liver of the lactating dairy cow.
Journal of theoretical biology 228, 271-289 [PubMed:15094021]
[show Abstract]
Norenberg MD, Jayakumar AR, Rama Rao KV (2004)
Oxidative stress in the pathogenesis of hepatic encephalopathy.
Metabolic brain disease 19, 313-329 [PubMed:15554424]
[show Abstract]
Rama Rao KV, Chen M, Simard JM, Norenberg MD (2003)
Increased aquaporin-4 expression in ammonia-treated cultured astrocytes.
Neuroreport 14, 2379-2382 [PubMed:14663195]
[show Abstract]
Lai DZ, Fu L, Yu CM, Qi LQ, Weng SJ, Yu T, Wang HT, Chen W (2003)
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[show Abstract]
Baum MM, Kiyomiya ES, Kumar S, Lappas AM, Kapinus VA, Lord HC (2001)
Multicomponent remote sensing of vehicle exhaust by dispersive absorption spectroscopy. 2. Direct on-road ammonia measurements.
Environmental science & technology 35, 3735-3741 [PubMed:11783653]
[show Abstract]
Bai G, Rama Rao KV, Murthy CR, Panickar KS, Jayakumar AR, Norenberg MD (2001)
Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes.
Journal of neuroscience research 66, 981-991 [PubMed:11746427]
[show Abstract]
Blei AT (2000)
Diagnosis and treatment of hepatic encephalopathy.
Bailliere's best practice & research. Clinical gastroenterology 14, 959-974 [PubMed:11139349]
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Fox SW (1995)
Thermal synthesis of amino acids and the origin of life.
Geochimica et cosmochimica acta 59, 1213-1214 [PubMed:11540049]
[show Abstract]
Schnell S, King GM (1994)
Mechanistic analysis of ammonium inhibition of atmospheric methane consumption in forest soils.
Applied and environmental microbiology 60, 3514-3521 [PubMed:16349403]
[show Abstract]
Nawaz MS, Chapatwala KD, Wolfram JH (1989)
Degradation of Acetonitrile by Pseudomonas putida.
Applied and environmental microbiology 55, 2267-2274 [PubMed:16348008]
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Mierzwiński A, Witkiewicz Z (1989)
The application of piezoelectric detectors for investigations of environmental pollution.
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Nelson DD, Fraser GT, Klemperer W (1987)
Does ammonia hydrogen bond?
Science (New York, N.Y.) 238, 1670-1674 [PubMed:17737668]
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Sakano K, Tazawa M (1985)
Metabolic Conversion of Amino Acids Loaded in the Vacuole of Chara australis Internodal Cells.
Plant physiology 78, 673-677 [PubMed:16664306]
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Gregoriou M, Brown PR (1979)
Inhibition of the aliphatic amidase from Pseudomonas aeruginosa by urea and related compounds.
European journal of biochemistry 96, 101-108 [PubMed:110589]
[show Abstract]
KOZLOV NB (1960)
[Effect of carbon dioxide on blood ammonia, glutamine and urea after the administration of ammonium chloride in animals].
Biulleten' eksperimental'noi biologii i meditsiny 50, 73-78 [PubMed:13753780]
Last Modified
09 December 2024