CHEBI:167636 - AZT-1152

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ChEBI Name AZT-1152
ChEBI ID CHEBI:167636
Definition A dihydrogen phosphate prodrug of a pyrazoloquinazoline aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide(HQPA) and is converted rapidly to the active AZD1152-HQPA in plasma.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formula C26H31FN7O6P
Net Charge 0
Average Mass 587.549
Monoisotopic Mass 587.20575
InChI InChI=1S/C26H31FN7O6P/c1-2-34(10-12-40-41(36,37)38)9-4-11-39-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(35)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17H,2,4,9-12,15H2,1H3,(H,30,35)(H2,36,37,38)(H2,28,29,31,32,33)
InChIKey GBJVVSCPOBPEIT-UHFFFAOYSA-N
SMILES CCN(CCCOC1=CC2=C(C=C1)C(NC1=NNC(CC(=O)NC3=CC(F)=CC=C3)=C1)=NC=N2)CCOP(O)(O)=O
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): Aurora kinase inhibitor
Any protein kinase inhibitor that inhibits the action of an Aurora kinase (a group of serine/threonine kinases that are essential for cell proliferation).
Application(s): prodrug
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing AZT-1152 (CHEBI:167636) has functional parent AZD-1152 (CHEBI:91367)
AZT-1152 (CHEBI:167636) has role antineoplastic agent (CHEBI:35610)
AZT-1152 (CHEBI:167636) has role Aurora kinase inhibitor (CHEBI:70770)
AZT-1152 (CHEBI:167636) has role prodrug (CHEBI:50266)
AZT-1152 (CHEBI:167636) is a anilide (CHEBI:13248)
AZT-1152 (CHEBI:167636) is a monoalkyl phosphate (CHEBI:25381)
AZT-1152 (CHEBI:167636) is a monofluorobenzenes (CHEBI:83575)
AZT-1152 (CHEBI:167636) is a pyrazoles (CHEBI:26410)
AZT-1152 (CHEBI:167636) is a quinazolines (CHEBI:38530)
AZT-1152 (CHEBI:167636) is a secondary amino compound (CHEBI:50995)
AZT-1152 (CHEBI:167636) is a secondary carboxamide (CHEBI:140325)
AZT-1152 (CHEBI:167636) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
2-[ethyl(3-{[4-({5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl}amino)quinazolin-7-yl]oxy}propyl)amino]ethyl dihydrogen phosphate
INNs Sources
barasertib ChEBI
barasertib ChEBI
barasertib ChEBI
barasertibum ChEBI
Synonyms Sources
AZD1152-HQPA dihydrogen phosphate ChEBI
AZD2811 ChEBI
INH-34 ChEBI
Manual Xref Database
DB11747 DrugBank
View more database links
Registry Numbers Types Sources
722543-31-9 CAS Registry Number ChemIDplus
957881-03-7 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
30 March 2021