CHEBI:17544 - hydrogencarbonate

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ChEBI Name hydrogencarbonate
ChEBI ID CHEBI:17544
Definition The carbon oxoanion resulting from the removal of a proton from carbonic acid.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:22863, CHEBI:40961, CHEBI:5589, CHEBI:13363
Supplier Information ChemicalBook:CB4336930, ChemicalBook:CB3699656, ChemicalBook:CB92675917, eMolecules:539665, Selleckchem:Ibuprofen(Advil)
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Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, fever, and inflammation. This includes painful menstrual periods, migraines, and rheumatoid arthritis. It may also be used to close a patent ductus arteriosus in a premature baby. It can be taken orally (by mouth) or intravenously. It typically begins working within an hour. Common side effects include heartburn, nausea, indigestion, and abdominal pain. As with other NSAIDs, potential side effects include gastrointestinal bleeding. Long-term use has been associated with kidney failure, and rarely liver failure, and it can exacerbate the condition of patients with heart failure. At low doses, it does not appear to increase the risk of heart attack; however, at higher doses it may. Ibuprofen can also worsen asthma. While its safety in early pregnancy is unclear, it appears to be harmful in later pregnancy, so it is not recommended during that period. Like other NSAIDs, it works by inhibiting the production of prostaglandins by decreasing the activity of the enzyme cyclooxygenase (COX). Ibuprofen is a weaker anti-inflammatory agent than other NSAIDs. Ibuprofen was discovered in 1961 by Stewart Adams and John Nicholson while working at Boots UK Limited and initially marketed as Brufen. It is available under a number of brand names including Advil, Motrin, and Nurofen. Ibuprofen was first marketed in 1969 in the United Kingdom and in 1974 in the United States. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2022, it was the 33rd most commonly prescribed medication in the United States, with more than 17 million prescriptions.
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Formula CHO3
Net Charge -1
Average Mass 61.01684
Monoisotopic Mass 60.99312
InChI InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1
InChIKey BVKZGUZCCUSVTD-UHFFFAOYSA-M
SMILES OC([O-])=O
Metabolite of Species Details
Mus musculus (NCBI:txid10090) Source: BioModels - MODEL1507180067 See: PubMed
Saccharomyces cerevisiae (NCBI:txid4932) Source: yeast.sf.net See: PubMed
Escherichia coli (NCBI:txid562) See: PubMed
Homo sapiens (NCBI:txid9606) See: DOI
Roles Classification
Biological Role(s): Escherichia coli metabolite
Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.
Saccharomyces cerevisiae metabolite
Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae ).
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
cofactor
An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
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ChEBI Ontology
Outgoing hydrogencarbonate (CHEBI:17544) has role Escherichia coli metabolite (CHEBI:76971)
hydrogencarbonate (CHEBI:17544) has role Saccharomyces cerevisiae metabolite (CHEBI:75772)
hydrogencarbonate (CHEBI:17544) has role cofactor (CHEBI:23357)
hydrogencarbonate (CHEBI:17544) has role human metabolite (CHEBI:77746)
hydrogencarbonate (CHEBI:17544) has role mouse metabolite (CHEBI:75771)
hydrogencarbonate (CHEBI:17544) is a carbon oxoanion (CHEBI:35604)
hydrogencarbonate (CHEBI:17544) is conjugate acid of carbonate (CHEBI:41609)
hydrogencarbonate (CHEBI:17544) is conjugate base of carbonic acid (CHEBI:28976)
Incoming potassium hydrogencarbonate (CHEBI:81862) has part hydrogencarbonate (CHEBI:17544)
sodium hydrogencarbonate (CHEBI:32139) has part hydrogencarbonate (CHEBI:17544)
hydrogen (13C)carbonate (CHEBI:140315) is a hydrogencarbonate (CHEBI:17544)
carbonic acid (CHEBI:28976) is conjugate acid of hydrogencarbonate (CHEBI:17544)
carbonate (CHEBI:41609) is conjugate base of hydrogencarbonate (CHEBI:17544)
IUPAC Names
hydrogen(trioxidocarbonate)(1−)
hydrogencarbonate
hydrogencarbonate(1−)
hydrogentrioxocarbonate(1−)
hydrogentrioxocarbonate(IV)
hydroxidodioxidocarbonate(1−)
Synonyms Sources
[CO2(OH)] IUPAC
Acid carbonate KEGG COMPOUND
Bicarbonate KEGG COMPOUND
BICARBONATE ION PDBeChem
HCO3 IUPAC
HCO3- KEGG COMPOUND
hydrogen carbonate PDBeChem
Hydrogencarbonate KEGG COMPOUND
hydrogencarbonate UniProt
Manual Xrefs Databases
BCT PDBeChem
Bicarbonate Wikipedia
C00288 KEGG COMPOUND
HCO3 MetaCyc
HMDB0000595 HMDB
View more database links
Registry Numbers Types Sources
3903504 Beilstein Registry Number Beilstein
49249 Gmelin Registry Number Gmelin
71-52-3 CAS Registry Number ChemIDplus
Citations Types Sources
17215880 PubMed citation Europe PMC
17505962 PubMed citation Europe PMC
18439416 PubMed citation Europe PMC
28732801 PubMed citation Europe PMC
29150416 PubMed citation Europe PMC
29460248 PubMed citation Europe PMC
29466234 PubMed citation Europe PMC
4208463 PubMed citation Europe PMC
Last Modified
30 August 2023