RK-24466 (CHEBI:180499)

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ChEBI Name	RK-24466

ChEBI ID	CHEBI:180499

Definition	A member of the class of pyrrolopyrimidines that is 7H-pyrrolo[2,3-d]pyrimidine substituted by amino, 4-phenoxyphenyl, and cyclopentyl groups at positions 4, 5 and 7, respectively. It is a potent inhibitor of Lck that inhibits Lck (64-509) and LckCD isoforms (IC₅₀ of less than 1 and 2 nM, respectively).

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C23H22N4O

Net Charge

Average Mass

370.456

Monoisotopic Mass

370.17936

InChI

InChI=1S/C23H22N4O/c24-22-21-20(14-27(17-6-4-5-7-17)23(21)26-15-25-22)16-10-12-19(13-11-16)28-18-8-2-1-3-9-18/h1-3,8-15,17H,4-7H2,(H2,24,25,26)

InChIKey

FMETVQKSDIOGPX-UHFFFAOYSA-N

SMILES

NC1=C2C(=NC=N1)N(C=C2C1=CC=C(OC2=CC=CC=C2)C=C1)C1CCCC1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2).

Application(s):	geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.

ChEBI Ontology
Outgoing	RK-24466 (CHEBI:180499) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617) RK-24466 (CHEBI:180499) has role geroprotector (CHEBI:176497) RK-24466 (CHEBI:180499) is a aromatic amine (CHEBI:33860) RK-24466 (CHEBI:180499) is a aromatic ether (CHEBI:35618) RK-24466 (CHEBI:180499) is a cyclopentanes (CHEBI:23493) RK-24466 (CHEBI:180499) is a primary amino compound (CHEBI:50994) RK-24466 (CHEBI:180499) is a pyrrolopyrimidine (CHEBI:38670)

IUPAC Name

7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Synonyms	Sources
4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[3,2-d]pyrimidin-7-yl-cyclopentane	ChEBI
7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine	ChEBI
KIN 001-51	ChEBI
KIN001-051	ChEBI
RK 24466	ChEBI
RK24466	ChEBI

Registry Number	Type	Source
213743-31-8	CAS Registry Number	ChEBI

Last Modified

22 September 2021