CHEBI:183634 - LY-367,265

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ChEBI Name LY-367,265
ChEBI ID CHEBI:183634
Definition A fluoroindole that is 1H-indole in which the hydrogens at positions 3 and 6 are replaced by 1-[2-(2,2-dioxo-5,6-dihydro-4H-2λ6-[1,2,5]thiadiazolo[4,3,2-ij]quinolin-1(2H)-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl and fluoro groups, respectively. It is an inhibitor of the 5-hydroxytryptamine transporter (Ki = 2.3 nM) and an antagonist of 5-hydroxytryptamine(2A) receptor (Ki = 0.81 nM).
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C24H25FN4O2S
Net Charge 0
Average Mass 452.550
Monoisotopic Mass 452.16823
InChI InChI=1S/C24H25FN4O2S/c25-19-6-7-20-21(16-26-22(20)15-19)17-8-11-27(12-9-17)13-14-28-23-5-1-3-18-4-2-10-29(24(18)23)32(28,30)31/h1,3,5-8,15-16,26H,2,4,9-14H2
InChIKey BJIPVHLRWSDKOS-UHFFFAOYSA-N
SMILES FC1=CC2=C(C=C1)C(=CN2)C1=CCN(CCN2C3=CC=CC4=C3N(CCC4)S2(=O)=O)CC1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
serotonin uptake inhibitor
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
Application(s): antidepressant
Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
geroprotector
Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
serotonin uptake inhibitor
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
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ChEBI Ontology
Outgoing LY-367,265 (CHEBI:183634) has role antidepressant (CHEBI:35469)
LY-367,265 (CHEBI:183634) has role geroprotector (CHEBI:176497)
LY-367,265 (CHEBI:183634) has role serotonergic antagonist (CHEBI:48279)
LY-367,265 (CHEBI:183634) has role serotonin uptake inhibitor (CHEBI:50949)
LY-367,265 (CHEBI:183634) is a dihydropyridine (CHEBI:50075)
LY-367,265 (CHEBI:183634) is a fluoroindole (CHEBI:131960)
LY-367,265 (CHEBI:183634) is a tertiary amino compound (CHEBI:50996)
LY-367,265 (CHEBI:183634) is a thiadiazoloquinoline (CHEBI:183635)
IUPAC Name
1-{2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydropyridin-1(2H)-yl]ethyl}-5,6-dihydro-1H,4H-[1,2,5]thiadiazolo[4,3,2-ij]quinoline 2,2-dioxide
Synonyms Sources
1-{2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydropyridin-1(2H)-yl]ethyl}-5,6-dihydro-4H-2λ6-[1,2,5]thiadiazolo[4,3,2-ij]quinoline-2,2(1H)-dione IUPAC
LY 367265 ChemIDplus
LY-367265 ChEBI
LY367265 ChemIDplus
Manual Xrefs Databases
3797242 ChemSpider
LY-367,265 Wikipedia
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Registry Number Type Source
210751-39-6 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
11050288 PubMed citation Europe PMC
15602751 PubMed citation Europe PMC
20149649 PubMed citation Europe PMC
21616779 PubMed citation Europe PMC
21823597 PubMed citation Europe PMC
24134630 PubMed citation Europe PMC
Last Modified
09 November 2021