CHEBI:195559 - poziotinib

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ChEBI Name poziotinib
ChEBI ID CHEBI:195559
Definition A member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, [1-(prop-2-enoyl)piperidin-4-yl]oxy, and methoxy groups at positions 4, 6, and 7, respectively. It is a potent and irreversible tyrosine kinase inhibitor targeting EGFR and HER2 with exon 20 insertion mutations.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C23H21Cl2FN4O3
Net Charge 0
Average Mass 491.340
Monoisotopic Mass 490.09747
InChI InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)
InChIKey LPFWVDIFUFFKJU-UHFFFAOYSA-N
SMILES COC1=CC2=NC=NC(NC3=CC=C(Cl)C(Cl)=C3F)=C2C=C1OC1CCN(CC1)C(=O)C=C
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
epidermal growth factor receptor antagonist
An antagonist at the epidermal growth factor receptor.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing poziotinib (CHEBI:195559) has role antineoplastic agent (CHEBI:35610)
poziotinib (CHEBI:195559) has role apoptosis inducer (CHEBI:68495)
poziotinib (CHEBI:195559) has role epidermal growth factor receptor antagonist (CHEBI:74440)
poziotinib (CHEBI:195559) is a N-acylpiperidine (CHEBI:48591)
poziotinib (CHEBI:195559) is a acrylamides (CHEBI:22216)
poziotinib (CHEBI:195559) is a aromatic ether (CHEBI:35618)
poziotinib (CHEBI:195559) is a dichlorobenzene (CHEBI:23697)
poziotinib (CHEBI:195559) is a diether (CHEBI:46786)
poziotinib (CHEBI:195559) is a monofluorobenzenes (CHEBI:83575)
poziotinib (CHEBI:195559) is a quinazolines (CHEBI:38530)
poziotinib (CHEBI:195559) is a secondary amino compound (CHEBI:50995)
poziotinib (CHEBI:195559) is a substituted aniline (CHEBI:48975)
IUPAC Name
1-(4-{[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy}piperidin-1-yl)prop-2-en-1-one
INNs Sources
poziotinib WHO MedNet
poziotinib WHO MedNet
poziotinib WHO MedNet
poziotinibum WHO MedNet
Synonyms Sources
1-[4-[[4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-propen-1-one ChEBI
HM 781-36B DrugBank
HM-781-36B DrugBank
HM781-36B ChEBI
NOV 120101 ChEBI
NOV-1201 ChEBI
NOV-120101 ChEBI
NOV120101 ChEBI
Manual Xrefs Databases
30687714 ChemSpider
D12229 KEGG DRUG
DB12114 DrugBank
Poziotinib Wikipedia
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Registry Number Type Source
1092364-38-9 CAS Registry Number DrugBank
Citations Waiting for Citations Types Sources
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Last Modified
18 August 2023