CHEBI:228283 - 7-ethoxy-N3-(2-furanylmethyl)-3,9-acridinediamine

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ChEBI Name 7-ethoxy-N3-(2-furanylmethyl)-3,9-acridinediamine
ChEBI ID CHEBI:228283
ChEBI ASCII Name 7-ethoxy-N(3)-(2-furanylmethyl)-3,9-acridinediamine
Definition A member of the class of aminoacridines that is acridin-9-amine substituted by [(furan-2-yl)methyl]amino and ethoxy groups at positions 3 and 7, respectively. It is a lysine deficient protein kinase (WNK) signaling inhibitor (IC50 = 16 μM).
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Doug Howe
Supplier Information
Download Molfile XML SDF
Formula C20H19N3O2
Net Charge 0
Average Mass 333.391
Monoisotopic Mass 333.14773
InChI InChI=1S/C20H19N3O2/c1-2-24-14-6-8-18-17(11-14)20(21)16-7-5-13(10-19(16)23-18)22-12-15-4-3-9-25-15/h3-11,22H,2,12H2,1H3,(H2,21,23)
InChIKey PGNWQNJXXLPZEL-UHFFFAOYSA-N
SMILES CCOC1=CC2=C(N)C3=C(C=C(NCC4=CC=CO4)C=C3)N=C2C=C1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): WNK signaling inhibitor
A substance that inhibits any of the WNK signalling pathway.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing 7-ethoxy-N3-(2-furanylmethyl)-3,9-acridinediamine (CHEBI:228283) has role WNK signaling inhibitor (CHEBI:228284)
7-ethoxy-N3-(2-furanylmethyl)-3,9-acridinediamine (CHEBI:228283) is a aminoacridines (CHEBI:51803)
7-ethoxy-N3-(2-furanylmethyl)-3,9-acridinediamine (CHEBI:228283) is a aromatic amine (CHEBI:33860)
7-ethoxy-N3-(2-furanylmethyl)-3,9-acridinediamine (CHEBI:228283) is a aromatic ether (CHEBI:35618)
7-ethoxy-N3-(2-furanylmethyl)-3,9-acridinediamine (CHEBI:228283) is a furans (CHEBI:24129)
IUPAC Name
7-ethoxy-N3-(furan-2-ylmethyl)acridine-3,9-diamine
Synonyms Sources
7-ethoxy-N3-[(furan-2-yl)methyl]acridine-3,9-diamine IUPAC
compound B
Note: (2023-12-14) ambiguous synonym
 ChEBI
STOCK2S 26016 ChEBI
STOCK2S-26016 ChEBI
WNK IN B ChEBI
WNK-IN-B ChEBI
Registry Number Type Source
332922-63-1 CAS Registry Number ChEBI
Citations Waiting for Citations Types Sources
27815594 PubMed citation Europe PMC
32592815 PubMed citation Europe PMC
33513812 PubMed citation Europe PMC
34312216 PubMed citation Europe PMC
35545295 PubMed citation SUBMITTER
Last Modified
14 December 2023