desloratadine (CHEBI:291342)

ChEBI > Main

Main

ChEBI Ontology

Automatic Xrefs

Reactions

Pathways

Models

ChEBI Name	desloratadine

ChEBI ID	CHEBI:291342

Definition	Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Wikipedia	License

Read full article at Wikipedia

Formula

C19H19ClN2

Net Charge

Average Mass

310.82100

Monoisotopic Mass

310.12368

InChI

InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2

InChIKey

JAUOIFJMECXRGI-UHFFFAOYSA-N

SMILES

Clc1ccc2c(CCc3cccnc3C2=C2CCNCC2)c1

Roles Classification
Biological Role(s):	H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists. drug metabolite

Application(s):	H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. anti-allergic agent A drug used to treat allergic reactions. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.

ChEBI Ontology
Outgoing	desloratadine (CHEBI:291342) has role anti-allergic agent (CHEBI:50857) desloratadine (CHEBI:291342) has role cholinergic antagonist (CHEBI:48873) desloratadine (CHEBI:291342) has role drug metabolite (CHEBI:49103) desloratadine (CHEBI:291342) has role H₁-receptor antagonist (CHEBI:37955) desloratadine (CHEBI:291342) is a benzocycloheptapyridine (CHEBI:48593)

Incoming	loratadine (CHEBI:6538) has functional parent desloratadine (CHEBI:291342)

IUPAC Name

8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

INN	Source
desloratadine	KEGG DRUG

Synonyms	Sources
8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine	ChEMBL
8-chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine	ChemIDplus
descarboethoxyloratadine	ChemIDplus
DESLORATADINE	ChEMBL

Last Modified

29 October 2021