profenamine (CHEBI:313639)

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ChEBI Name	profenamine

ChEBI ID	CHEBI:313639

Definition	A member of the class of phenothiazines that is phenothiazine in which the hydrogen attached to the nitrogen is substituted by a 2-(diethylamino)propyl group. An antimuscarinic, it is used as the hydrochloride for the symptomatic treatment of Parkinson's disease.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information	We are unable to retrieve the vendor information for this entry at this time. Please try again later.

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Wikipedia	License
Profenamine (INN; also known as ethopropazine (BAN); solde under the trade name Parsidol and others) is a phenothiazine derivative used as an antiparkinsonian agent that has anticholinergic, antihistamine, and antiadrenergic actions. It is also used in the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against tardive dyskinesia.
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Formula

C19H24N2S

Net Charge

Average Mass

312.47200

Monoisotopic Mass

312.16602

InChI

InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3

InChIKey

CDOZDBSBBXSXLB-UHFFFAOYSA-N

SMILES

CCN(CC)C(C)CN1c2ccccc2Sc2ccccc12

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. histamine antagonist Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. adrenergic antagonist An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.

Application(s):	muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. antiparkinson drug A drug used in the treatment of Parkinson's disease. histamine antagonist Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. adrenergic antagonist An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. antidyskinesia agent Any compound which can be used to treat or alleviate the symptoms of dyskinesia.

ChEBI Ontology
Outgoing	profenamine (CHEBI:313639) has role adrenergic antagonist (CHEBI:37887) profenamine (CHEBI:313639) has role antidyskinesia agent (CHEBI:66956) profenamine (CHEBI:313639) has role antiparkinson drug (CHEBI:48407) profenamine (CHEBI:313639) has role histamine antagonist (CHEBI:37956) profenamine (CHEBI:313639) has role muscarinic antagonist (CHEBI:48876) profenamine (CHEBI:313639) is a phenothiazines (CHEBI:38093) profenamine (CHEBI:313639) is a tertiary amino compound (CHEBI:50996)

Incoming	profenamine hydrochloride (CHEBI:31568) has part profenamine (CHEBI:313639) (R)-profenamine (CHEBI:60348) is a profenamine (CHEBI:313639) (S)-profenamine (CHEBI:60349) is a profenamine (CHEBI:313639)

IUPAC Name

N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine

Synonyms	Sources
10-(2-diethylaminopropyl)phenothiazine	ChemIDplus
10-[2-(diethylamino)-1-propyl]phenothiazine	NIST Chemistry WebBook
10-[2-(diethylamino)-2-methylethyl]phenothiazine	NIST Chemistry WebBook
10-[2-(diethylamino)propyl]phenothiazine	NIST Chemistry WebBook
2-diethylamino-1-propyl-N-dibenzoparathiazine	ChemIDplus
ethopropazine	ChemIDplus
N,N-diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine	NIST Chemistry WebBook
N,N-diethyl-α-methyl-10H-phenothiazine-10-ethanamine	NIST Chemistry WebBook

Last Modified

22 February 2017