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InChI=1S/CH4O/c1-2/h2H,1H3
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CHEBI:31399 - cilnidipine
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ChEBI Name
cilnidipine
ChEBI ID
CHEBI:31399
Definition
A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.
Stars
This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs
CHEBI:551341
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Formula
C27H28N2O7
Net Charge
0
Average Mass
492.52040
Monoisotopic Mass
492.18965
InChI
InChI=1S/C27H28N2O7/c1-
18-
23(26(30)
35-
14-
8-
11-
20-
9-
5-
4-
6-
10-
20)
25(21-
12-
7-
13-
22(17-
21)
29(32)
33)
24(19(2)
28-
18)
27(31)
36-
16-
15-
34-
3/h4-
13,17,25,28H,14-
16H2,1-
3H3/b11-
8+
InChIKey
KJEBULYHNRNJTE-DHZHZOJOSA-N
SMILES
COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC\C=C\c1ccccc1
Roles Classification
Biological Role
(s):
calcium channel blocker
One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
Application
(s):
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
cardiovascular drug
A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
cilnidipine (
CHEBI:31399
)
has role
antihypertensive agent (
CHEBI:35674
)
cilnidipine (
CHEBI:31399
)
has role
calcium channel blocker (
CHEBI:38215
)
cilnidipine (
CHEBI:31399
)
has role
cardiovascular drug (
CHEBI:35554
)
cilnidipine (
CHEBI:31399
)
is a
2-methoxyethyl ester (
CHEBI:136838
)
cilnidipine (
CHEBI:31399
)
is a
C
-nitro compound (
CHEBI:35716
)
cilnidipine (
CHEBI:31399
)
is a
dihydropyridine (
CHEBI:50075
)
IUPAC Name
2-
methoxyethyl (2
E
)-
3-
phenylprop-
2-
en-
1-
yl 2,6-
dimethyl-
4-
(3-
nitrophenyl)-
1,4-
dihydropyridine-
3,5-
dicarboxylate
INN
Source
cilnidipine
ChemIDplus
Synonym
Source
(±)-
(
E
)-
cinnamyl 2-
methoxyethyl 1,4-
dihydro-
2,6-
dimethyl-
4-
(
m
-
nitrophenyl)-
3,5-
pyridinedicarboxylate
ChemIDplus
Manual Xrefs
Databases
642
DrugCentral
Cilnidipine
Wikipedia
D01173
KEGG DRUG
EP161877
Patent
US4672068
Patent
View more database links
Registry Number
Type
Source
132203-70-4
CAS Registry Number
ChemIDplus
Last Modified
13 April 2017