bretylium tosylate (CHEBI:3173)

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ChEBI Name	bretylium tosylate

ChEBI ID	CHEBI:3173

Definition	The tosylate salt of bretylium. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C18H24BrNO3S

Net Charge

Average Mass

414.35700

Monoisotopic Mass

413.06603

InChI

InChI=1S/C11H17BrN.C7H8O3S/c1-4-13(2,3)9-10-7-5-6-8-11(10)12;1-6-2-4-7(5-3-6)11(8,9)10/h5-8H,4,9H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1

InChIKey

KVWNWTZZBKCOPM-UHFFFAOYSA-M

SMILES

Cc1ccc(cc1)S([O-])(=O)=O.CC[N+](C)(C)Cc1ccccc1Br

Roles Classification
Biological Role(s):	adrenergic antagonist An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.

Application(s):	adrenergic antagonist An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.

ChEBI Ontology
Outgoing	bretylium tosylate (CHEBI:3173) has part bretylium (CHEBI:3172) bretylium tosylate (CHEBI:3173) has role adrenergic antagonist (CHEBI:37887) bretylium tosylate (CHEBI:3173) has role anti-arrhythmia drug (CHEBI:38070) bretylium tosylate (CHEBI:3173) has role antihypertensive agent (CHEBI:35674) bretylium tosylate (CHEBI:3173) is a organosulfonate salt (CHEBI:64382) bretylium tosylate (CHEBI:3173) is a quaternary ammonium salt (CHEBI:35273)

IUPAC Name

N-(2-bromobenzyl)-N,N-dimethylethanaminium 4-methylbenzenesulfonate

Synonyms	Sources
(2-bromobenzyl)ethyldimethylammonium toluene-4-sulfonate	ChEBI
(2-bromobenzyl)ethyldimethylammonium tosylate	ChEBI
(o-bromobenzyl)ethyldimethylammonium p-toluenesulfonate	ChemIDplus
2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium 4-methylbenzenesulfonate	ChemIDplus
bretylii tosilas	ChemIDplus
dimethylethyl-o-bromobenzylammonium-p-toluenesulphonate	ChemIDplus
N-ethyl-N-o-bromobenzyl-N,N-dimethylammonium tosylate	ChemIDplus

Last Modified

18 April 2012