tenoxicam (CHEBI:32192)

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ChEBI Name	tenoxicam

ChEBI ID	CHEBI:32192

Definition	A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for the treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis. It is also indicated for short term treatment of acute musculoskeletal disorders including strains, sprains and other soft-tissue injuries.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information	eMolecules:26749763, ZINC000095622485

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Formula

C13H11N3O4S2

Net Charge

Average Mass

337.37400

Monoisotopic Mass

337.01910

InChI

InChI=1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)

InChIKey

LZNWYQJJBLGYLT-UHFFFAOYSA-N

SMILES

CN1C(C(=O)Nc2ccccn2)=C(O)c2sccc2S1(=O)=O

Roles Classification
Biological Role(s):	non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.

Application(s):	non-steroidal anti-inflammatory drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. antipyretic A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.

ChEBI Ontology
Outgoing	tenoxicam (CHEBI:32192) has role antipyretic (CHEBI:35493) tenoxicam (CHEBI:32192) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544) tenoxicam (CHEBI:32192) has role non-narcotic analgesic (CHEBI:35481) tenoxicam (CHEBI:32192) has role non-steroidal anti-inflammatory drug (CHEBI:35475) tenoxicam (CHEBI:32192) is a heteroaryl hydroxy compound (CHEBI:74818) tenoxicam (CHEBI:32192) is a monocarboxylic acid amide (CHEBI:29347) tenoxicam (CHEBI:32192) is a pyridines (CHEBI:26421) tenoxicam (CHEBI:32192) is a thienothiazine (CHEBI:46977)

IUPAC Name

4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide

Last Modified

19 June 2017