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ChEBI
> Main
CHEBI:34385 - 4-aminopyridine
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ChEBI Ontology
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ChEBI Name
4-aminopyridine
ChEBI ID
CHEBI:34385
Definition
An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.
Stars
This entity has been manually annotated by the ChEBI Team.
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Wikipedia
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Read full article at Wikipedia
Formula
C5H6N2
Net Charge
0
Average Mass
94.11462
Monoisotopic Mass
94.05310
InChI
InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
InChIKey
NUKYPUAOHBNCPY-UHFFFAOYSA-N
SMILES
Nc1ccncc1
Roles Classification
Chemical Role
(s):
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Br
o
nsted acid).
(via
organic amino compound
)
Biological Role
(s):
potassium channel blocker
An agent that inhibits cell membrane glycoproteins that are selectively permeable to potassium ions.
Application
(s):
orphan drug
Any drug that has been developed specifically for treatment of a rare medical condition, the condition itself being known as an orphan disease.
avicide
A substance used to destroy bird pests (class
Aves
).
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
4-aminopyridine (
CHEBI:34385
)
has role
avicide (
CHEBI:33289
)
4-aminopyridine (
CHEBI:34385
)
has role
orphan drug (
CHEBI:71031
)
4-aminopyridine (
CHEBI:34385
)
has role
potassium channel blocker (
CHEBI:50509
)
4-aminopyridine (
CHEBI:34385
)
is a
aminopyridine (
CHEBI:38207
)
4-aminopyridine (
CHEBI:34385
)
is a
aromatic amine (
CHEBI:33860
)
Incoming
4-aminonicotinic acid (
CHEBI:68577
)
has functional parent
4-aminopyridine (
CHEBI:34385
)
4-aminopyridine-3-methanol (
CHEBI:149772
)
has functional parent
4-aminopyridine (
CHEBI:34385
)
torasemide (
CHEBI:9637
)
has functional parent
4-aminopyridine (
CHEBI:34385
)
IUPAC Name
pyridin-4-amine
INNs
Sources
fampridina
WHO MedNet
fampridine
WHO MedNet
fampridine
KEGG DRUG
fampridinum
WHO MedNet
Synonyms
Sources
4-Aminopyridine
KEGG COMPOUND
4-AP
KEGG COMPOUND
4-Pyridinamine
ChemIDplus
4-Pyridylamine
ChemIDplus
Avitrol
ChemIDplus
Dalfampridine
KEGG DRUG
γ-Aminopyridine
NIST Chemistry WebBook
N07XX07
KEGG DRUG
p-Aminopyridine
ChemIDplus
Brand Name
Source
Ampyra
KEGG DRUG
Manual Xrefs
Databases
1348
PPDB
4163
DrugCentral
4AP
PDBeChem
C13728
KEGG COMPOUND
D04127
KEGG DRUG
Dalfampridine
Wikipedia
View more database links
Registry Numbers
Types
Sources
105782
Reaxys Registry Number
Reaxys
504-24-5
CAS Registry Number
NIST Chemistry WebBook
504-24-5
CAS Registry Number
ChemIDplus
Citations
Types
Sources
11049865
PubMed citation
Europe PMC
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12525889
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Last Modified
20 May 2020