clofibric acid (CHEBI:34648)

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ChEBI Name	clofibric acid

ChEBI ID	CHEBI:34648

Definition	A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Johnny Lloyd

Secondary ChEBI IDs	CHEBI:73161

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Formula

C10H11ClO3

Net Charge

Average Mass

214.64524

Monoisotopic Mass

214.03967

InChI

InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)

InChIKey

TXCGAZHTZHNUAI-UHFFFAOYSA-N

SMILES

CC(C)(Oc1ccc(Cl)cc1)C(O)=O

Roles Classification
Chemical Role(s):	Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). (via oxoacid )

Biological Role(s):	PPARalpha agonist A PPAR modulator which activates the peroxisome proliferator-activated receptor-alpha. marine xenobiotic metabolite Any metabolite produced by metabolism of a xenobiotic compound in marine macro- and microorganisms.

Application(s):	anticholesteremic drug A substance used to lower plasma cholesterol levels. antilipemic drug A substance used to treat hyperlipidemia (an excess of lipids in the blood). antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. herbicide A substance used to destroy plant pests.

ChEBI Ontology
Outgoing	clofibric acid (CHEBI:34648) has functional parent isobutyric acid (CHEBI:16135) clofibric acid (CHEBI:34648) has role anticholesteremic drug (CHEBI:35821) clofibric acid (CHEBI:34648) has role antilipemic drug (CHEBI:35679) clofibric acid (CHEBI:34648) has role antineoplastic agent (CHEBI:35610) clofibric acid (CHEBI:34648) has role herbicide (CHEBI:24527) clofibric acid (CHEBI:34648) has role marine xenobiotic metabolite (CHEBI:83399) clofibric acid (CHEBI:34648) has role PPARα agonist (CHEBI:70782) clofibric acid (CHEBI:34648) is a aromatic ether (CHEBI:35618) clofibric acid (CHEBI:34648) is a monocarboxylic acid (CHEBI:25384) clofibric acid (CHEBI:34648) is a monochlorobenzenes (CHEBI:83403)

Incoming	clofibrate (CHEBI:3750) has functional parent clofibric acid (CHEBI:34648)

IUPAC Name

2-(4-chlorophenoxy)-2-methylpropanoic acid

Synonyms	Sources
2-(4-Chlorophenoxy)-2-methylpropionic acid	ChemIDplus
2-(p-Chlorophenoxy)-2-methylpropionic acid	ChemIDplus
2-(p-Chlorophenoxy)isobutyric acid	ChemIDplus
4-CPIB	NIST Chemistry WebBook
Acide (p-chlorophenoxy)-2 methyl-2 propionique	ChemIDplus
α-(4-chlorophenoxy)-α-methylpropionic acid	NIST Chemistry WebBook
α-(p-chlorophenoxy)isobutyric acid	NIST Chemistry WebBook
Chlorfibrinic acid	ChemIDplus
Chlorofibrinic acid	ChemIDplus
Chlorophibrinic acid	ChemIDplus
Clofibrate free acid	ChemIDplus
Clofibric acid	KEGG COMPOUND
Clofibrinsäure	ChemIDplus
CPIB	NIST Chemistry WebBook
PCIB	NIST Chemistry WebBook
PCPIB	NIST Chemistry WebBook

Last Modified

22 February 2017

General Comments
2014-10-29	Metabolite of Clofibrate
2014-10-29	Stravs M, Schymanski E, Singer H, Department of Environmental Chemistry, Eawag