| Cisplatin is a chemical compound with formula cis-[Pt(NH3)2Cl2]. It is a coordination complex of platinum that is used as a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein.
Common side effects include bone marrow suppression, hearing problems including severe hearing loss, kidney damage, and vomiting. Other serious side effects include numbness, trouble walking, allergic reactions, electrolyte problems, and heart disease. Use during pregnancy can cause harm to the developing fetus. Cisplatin is in the platinum-based antineoplastic family of medications. It works in part by binding to DNA and inhibiting its replication.
Cisplatin was first reported in 1845 and licensed for medical use in 1978 and 1979. It is on the World Health Organization's List of Essential Medicines. |
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InChI=1S/C16H17N3O4S/c1- 8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1 |
| ZAIPMKNFIOOWCQ-UEKVPHQBSA-N |
| [H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccccc1)C(O)=O |
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antibacterial drug
A drug used to treat or prevent bacterial infections.
drug allergen
Any drug which causes the onset of an allergic reaction.
(via cephalosporin )
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
(via heterocyclic antibiotic )
allergen
A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.
(via beta-lactam antibiotic allergen )
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antibacterial drug
A drug used to treat or prevent bacterial infections.
drug allergen
Any drug which causes the onset of an allergic reaction.
(via cephalosporin )
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View more via ChEBI Ontology
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7β-[(2R)-2-amino-2-phenylacetamido]-3-methyl-3,4-didehydrocepham-4-carboxylic acid
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cefalexina
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ChemIDplus
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cefalexine
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ChemIDplus
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cefalexinum
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ChemIDplus
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(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
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IUPAC
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7-(D-α-Aminophenylacetamido)desacetoxycephalosporanic acid
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ChemIDplus
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7-β-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid
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ChemIDplus
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Cefalexin
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KEGG COMPOUND
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Celexin
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ChemIDplus
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Cepastar
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ChemIDplus
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Cepexin
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ChemIDplus
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Cephacillin
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ChemIDplus
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Ceporexin
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ChemIDplus
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CEX
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KEGG DRUG
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15686-71-2
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CAS Registry Number
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KEGG COMPOUND
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15686-71-2
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CAS Registry Number
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ChemIDplus
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4238892
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Reaxys Registry Number
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Reaxys
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965503
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Beilstein Registry Number
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Beilstein
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10930630
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PubMed citation
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Europe PMC
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12569987
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12833570
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Europe PMC
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1384868
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Europe PMC
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2083978
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Europe PMC
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22559990
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PubMed citation
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Europe PMC
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23061564
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PubMed citation
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Europe PMC
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23457080
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Europe PMC
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23545436
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Europe PMC
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24268227
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Europe PMC
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24548092
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Europe PMC
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29017833
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Europe PMC
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