CHEBI:3750 - clofibrate

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ChEBI Name clofibrate
ChEBI ID CHEBI:3750
Definition The ethyl ester of clofibric acid.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information ChemicalBook:CB5774380, eMolecules:492659, Selleckchem:Clofibrate(Atromid-S), ZINC000000056648
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Clofibrate (trade name Atromid-S) is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It belongs to the class of fibrates. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It can increase the level of HDL as well. It was patented in 1958 by Imperial Chemical Industries and approved for medical use in 1963. Clofibrate was discontinued in 2002 due to adverse effects.
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Formula C12H15ClO3
Net Charge 0
Average Mass 242.69900
Monoisotopic Mass 242.07097
InChI InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
InChIKey KNHUKKLJHYUCFP-UHFFFAOYSA-N
SMILES CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
Roles Classification
Biological Role(s): PPARalpha agonist
A PPAR modulator which activates the peroxisome proliferator-activated receptor-alpha.
Application(s): anticholesteremic drug
A substance used to lower plasma cholesterol levels.
antilipemic drug
A substance used to treat hyperlipidemia (an excess of lipids in the blood).
geroprotector
Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
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ChEBI Ontology
Outgoing clofibrate (CHEBI:3750) has functional parent clofibric acid (CHEBI:34648)
clofibrate (CHEBI:3750) has role anticholesteremic drug (CHEBI:35821)
clofibrate (CHEBI:3750) has role antilipemic drug (CHEBI:35679)
clofibrate (CHEBI:3750) has role geroprotector (CHEBI:176497)
clofibrate (CHEBI:3750) has role PPARα agonist (CHEBI:70782)
clofibrate (CHEBI:3750) is a aromatic ether (CHEBI:35618)
clofibrate (CHEBI:3750) is a ethyl ester (CHEBI:23990)
clofibrate (CHEBI:3750) is a monochlorobenzenes (CHEBI:83403)
IUPAC Name
ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
INNs Sources
clofibrate ChemIDplus
clofibrato ChemIDplus
clofibratum ChemIDplus
Synonyms Sources
2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester ChemIDplus
2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester ChemIDplus
alpha-(p-Chlorophenoxy)isobutyric acid, ethyl ester ChemIDplus
alpha-p-Chlorophenoxyisobutyryl ethyl ester ChemIDplus
Clofibrate KEGG COMPOUND
EPIB DrugBank
Ethyl 2-(p-chlorophenoxy)isobutyrate ChemIDplus
Ethyl chlorophenoxyisobutyrate ChemIDplus
Ethyl clofibrate ChemIDplus
Liprin ChemIDplus
Brand Names Sources
Atromid-S KEGG DRUG
ELPI DrugBank
Lipofacton DrugBank
Manual Xrefs Databases
2694 ChemSpider
694 DrugCentral
C06916 KEGG COMPOUND
Clofibrate Wikipedia
D00279 KEGG DRUG
DB00636 DrugBank
GB860303 Patent
HMDB0014774 HMDB
LSM-2996 LINCS
US3262850 Patent
View more database links
Registry Numbers Types Sources
1913459 Beilstein Registry Number Beilstein
637-07-0 CAS Registry Number ChemIDplus
637-07-0 CAS Registry Number NIST Chemistry WebBook
Citations Waiting for Citations
Last Modified
20 September 2021