CHEBI:37943 - colistin

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name colistin
ChEBI ID CHEBI:37943
Definition A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:34651, CHEBI:472593, CHEBI:566816, CHEBI:560465, CHEBI:600596, CHEBI:596826, CHEBI:597111, CHEBI:659853
Download Molfile XML SDF
Formula C52H97N16O13R
Net Charge 0
Average Mass (excl. R groups) 1154.428
Monoisotopic Mass (excl. R groups) 1153.74210
SMILES C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)NCC1)[C@@H](C)O)=O)CCN)=O)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)=O)CCN)=O)[C@@H](C)O)=O)CCN)=O)CCC[C@@H](C*)C
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): nephrotoxic agent
A role played by any chemical compound (natural or synthetic) exhibiting itself through the ability to induce damage to the kidneys.
antibacterial agent
A substance (or active part thereof) that kills or slows the growth of bacteria.
(via polymyxin )
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
(via polymyxin )
(via peptide antibiotic )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing colistin (CHEBI:37943) has part colistin A (CHEBI:59064)
colistin (CHEBI:37943) has part colistin B (CHEBI:59673)
colistin (CHEBI:37943) has role nephrotoxic agent (CHEBI:50909)
colistin (CHEBI:37943) is a peptide antibiotic (CHEBI:25903)
colistin (CHEBI:37943) is a polymyxin (CHEBI:59062)
Incoming colistimethate (CHEBI:59662) has functional parent colistin (CHEBI:37943)
colistimethate sodium (CHEBI:34650) has functional parent colistin (CHEBI:37943)
INNs Sources
colistina ChemIDplus
colistine ChemIDplus
colistinum ChemIDplus
Synonyms Sources
Colistin ChEMBL
polymyxin E ChemIDplus
Manual Xrefs Databases
C13768 KEGG COMPOUND
D02138 KEGG DRUG
DB00803 DrugBank
View more database links
Registry Numbers Types Sources
1066-17-7 CAS Registry Number ChemIDplus
1264-72-8 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
03 December 2019