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| deguelin |
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| CHEBI:4357 |
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| A rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers. |
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This entity has been manually annotated by the ChEBI Team.
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| ChemicalBook:CB9431676, eMolecules:29547187, eMolecules:1935628, ZINC000003978987 |
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Molfile
XML
SDF
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more structures >>
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InChI=1S/C23H22O6/c1- 23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1 |
| ORDAZKGHSNRHTD-UXHICEINSA-N |
| [H][C@@]12COC3=C(C=C(OC)C(OC)=C3)[C@]1([H])C(=O)C1=C(O2)C2=C(OC(C)(C)C=C2)C=C1 |
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Tephrosia vogelii
(NCBI:txid1157238)
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See:
PubMed
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Tephrosia purpurea
(NCBI:txid228354)
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See:
PubMed
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Mundulea sericea
(NCBI:txid54460)
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See:
PubMed
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apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
plant metabolite
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
antiviral agent
A substance that destroys or inhibits replication of viruses.
mitochondrial NADH:ubiquinone reductase inhibitor
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
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antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
anti-inflammatory agent
Any compound that has anti-inflammatory effects.
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View more via ChEBI Ontology
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(7aS,13aS)-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one
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(−)-cis-deguelin
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KNApSAcK
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(−)-deguelin
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ChEBI
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(7aS,13aS)-13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
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ChEBI
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(7aS,13aS)-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-pyrano[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-7(7aH)-one
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IUPAC
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522-17-8
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CAS Registry Number
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ChemIDplus
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27771933
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PubMed citation
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Europe PMC
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28471807
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29157837
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