CHEBI:45980 - tacrine

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ChEBI Name tacrine
ChEBI ID CHEBI:45980
Definition A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:45978, CHEBI:9389
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Formula C13H14N2
Net Charge 0
Average Mass 198.26374
Monoisotopic Mass 198.11570
InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
InChIKey YLJREFDVOIBQDA-UHFFFAOYSA-N
SMILES Nc1c2CCCCc2nc2ccccc12
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 3.1.1.7 (acetylcholinesterase) inhibitor
An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
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ChEBI Ontology
Outgoing tacrine (CHEBI:45980) has role EC 3.1.1.7 (acetylcholinesterase) inhibitor (CHEBI:38462)
tacrine (CHEBI:45980) is a acridines (CHEBI:22213)
tacrine (CHEBI:45980) is a aromatic amine (CHEBI:33860)
tacrine (CHEBI:45980) is conjugate base of tacrine(1+) (CHEBI:187896)
Incoming bis(7)-tacrine (CHEBI:138435) has functional parent tacrine (CHEBI:45980)
tacrine(1+) (CHEBI:187896) is conjugate acid of tacrine (CHEBI:45980)
IUPAC Name
1,2,3,4-tetrahydroacridin-9-amine
Synonyms Sources
1,2,3,4-tetrahydro-9-acridinamine NIST Chemistry WebBook
1,2,3,4-tetrahydro-9-aminoacridine NIST Chemistry WebBook
5-amino-6,7,8,9-tetrahydroacridine NIST Chemistry WebBook
9-amino-1,2,3,4-tetrahydroacridine NIST Chemistry WebBook
Tacrine KEGG COMPOUND
TACRINE PDBeChem
tetrahydroaminacrine ChemIDplus
Manual Xrefs Databases
2551 DrugCentral
C01453 KEGG COMPOUND
D08555 KEGG DRUG
DB00382 DrugBank
LSM-5871 LINCS
Tacrine Wikipedia
THA PDBeChem
View more database links
Registry Numbers Types Sources
147610 Beilstein Registry Number Beilstein
147610 Reaxys Registry Number Reaxys
321-64-2 CAS Registry Number NIST Chemistry WebBook
321-64-2 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
10817586 PubMed citation Europe PMC
24560791 PubMed citation Europe PMC
7866482 PubMed citation Europe PMC
Last Modified
22 February 2017