dipyridamole (CHEBI:4653)

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ChEBI Name	dipyridamole

ChEBI ID	CHEBI:4653

Definition	A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information	ChemicalBook:CB6731869, eMolecules:494752, eMolecules:27519521, Selleckchem:Dipyridamole(Permole,-Persantine), ZINC000000643046

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Wikipedia	License
Dipyridamole, sold under the brand name Persantine among others, is an antiplatelet drug of the nucleoside transport inhibitor and PDE3 inhibitor class that inhibits blood clot formation when given chronically and causes blood vessel dilation when given at high doses over a short time.
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Formula

C24H40N8O4

Net Charge

Average Mass

504.62592

Monoisotopic Mass

504.31725

InChI

InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2

InChIKey

IZEKFCXSFNUWAM-UHFFFAOYSA-N

SMILES

OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	adenosine phosphodiesterase inhibitor EC 3.5.4.4 (adenosine deaminase) inhibitor An EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor that interferes with the action of adenosine deaminase (EC 3.5.4.4).

Application(s):	platelet aggregation inhibitor A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. vasodilator agent A drug used to cause dilation of the blood vessels.

ChEBI Ontology
Outgoing	dipyridamole (CHEBI:4653) has role adenosine phosphodiesterase inhibitor (CHEBI:50444) dipyridamole (CHEBI:4653) has role EC 3.5.4.4 (adenosine deaminase) inhibitor (CHEBI:50445) dipyridamole (CHEBI:4653) has role platelet aggregation inhibitor (CHEBI:50427) dipyridamole (CHEBI:4653) has role vasodilator agent (CHEBI:35620) dipyridamole (CHEBI:4653) is a piperidines (CHEBI:26151) dipyridamole (CHEBI:4653) is a pyrimidopyrimidine (CHEBI:48514) dipyridamole (CHEBI:4653) is a tertiary amino compound (CHEBI:50996) dipyridamole (CHEBI:4653) is a tetrol (CHEBI:33573)

IUPAC Name

2,2',2'',2'''-[(4,8-dipiperidin-1-ylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol

Citations

Last Modified

22 February 2017