ethionamide (CHEBI:4885)

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ChEBI Name	ethionamide

ChEBI ID	CHEBI:4885

Definition	A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C8H10N2S

Net Charge

Average Mass

166.24448

Monoisotopic Mass

166.05647

InChI

InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)

InChIKey

AEOCXXJPGCBFJA-UHFFFAOYSA-N

SMILES

CCc1cc(ccn1)C(N)=S

Roles Classification
Biological Role(s):	antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. fatty acid synthesis inhibitor Any pathway inhibitor that inhibits the synthesis of fatty acids. leprostatic drug A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions.

Application(s):	antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. antilipemic drug A substance used to treat hyperlipidemia (an excess of lipids in the blood). leprostatic drug A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions. prodrug A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.

ChEBI Ontology
Outgoing	ethionamide (CHEBI:4885) has role antilipemic drug (CHEBI:35679) ethionamide (CHEBI:4885) has role antitubercular agent (CHEBI:33231) ethionamide (CHEBI:4885) has role fatty acid synthesis inhibitor (CHEBI:50185) ethionamide (CHEBI:4885) has role leprostatic drug (CHEBI:35816) ethionamide (CHEBI:4885) has role prodrug (CHEBI:50266) ethionamide (CHEBI:4885) is a pyridines (CHEBI:26421) ethionamide (CHEBI:4885) is a thiocarboxamide (CHEBI:47956)

Incoming	ethionamide S-oxide (CHEBI:87805) has functional parent ethionamide (CHEBI:4885)

IUPAC Name

2-ethylpyridine-4-carbothioamide

Brand Name	Source
Trecator	ChemIDplus

Last Modified

22 February 2017