CHEBI:49200 - EC 3.6.3.10 (H⁺/K⁺-exchanging ATPase) inhibitor

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ChEBI Name EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor ChEBI ID CHEBI:49200 ChEBI ASCII Name EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor Definition An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that inhibits H+/K+-exchanging ATPase, EC 3.6.3.10. Such compounds are also known as proton pump inhibitors. Stars This entity has been manually annotated by the ChEBI Team. Wikipedia License Proton-pump inhibitors (PPIs) are a class of medications that cause a profound and prolonged reduction of stomach acid production. They do so by irreversibly inhibiting the stomach's H+/K+ ATPase proton pump. The body eventually synthesizes new proton pumps to replace the irreversibly inhibited ones, a process driven by normal cellular turnover, which gradually restores acid production. Proton-pump inhibitors have largely superseded the H2-receptor antagonists, a group of medications with similar effects but a different mode of action, and heavy use of antacids. A potassium-competitive acid blocker (PCAB) revaprazan was marketed in Korea as an alternative to a PPI. A newer PCAB vonoprazan with a faster and longer lasting action than revaprazan, and PPIs has been marketed in Japan (2013), Russia (2021), and the US (2023). PPIs are among the most widely sold medications in the world. The class of proton-pump inhibitor medications is on the World Health Organization's List of Essential Medicines. Omeprazole is the specific listed example. Read full article at Wikipedia ChEBI Ontology Outgoing EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor (CHEBI:49200) is a EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor (CHEBI:76895) Incoming bafilomycin A1 (CHEBI:22689) has role EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor (CHEBI:49200) diethylstilbestrol (CHEBI:41922) has role EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor (CHEBI:49200) esomeprazole (CHEBI:50275) has role EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor (CHEBI:49200) esomeprazole magnesium (CHEBI:50309) has role EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor (CHEBI:49200) lansoprazole (CHEBI:6375) has role EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor (CHEBI:49200) omeprazole (CHEBI:7772) has role EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor (CHEBI:49200) optochin (CHEBI:86455) has role EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor (CHEBI:49200) ouabain (CHEBI:472805) has role EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor (CHEBI:49200) pantoprazole (CHEBI:7915) has role EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor (CHEBI:49200) pantoprazole sodium (CHEBI:50270) has role EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor (CHEBI:49200) rabeprazole (CHEBI:8768) has role EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor (CHEBI:49200) Synonyms Sources (K+ + H+)-ATPase inhibitor ChEBI (K+ + H+)-ATPase inhibitors ChEBI ATP phosphohydrolase (H+/K+-exchanging) inhibitor ChEBI ATP phosphohydrolase (H+/K+-exchanging) inhibitors ChEBI EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitors ChEBI EC 3.6.3.10 inhibitor ChEBI EC 3.6.3.10 inhibitors ChEBI H+-K+-ATPase inhibitor ChEBI H+-K+-ATPase inhibitors ChEBI H+/K+-ATPase inhibitor ChEBI H+/K+-ATPase inhibitors ChEBI H+/K+-exchanging ATPase inhibitor ChEBI H+/K+-exchanging ATPase inhibitors ChEBI H,K-ATPase inhibitor ChEBI H,K-ATPase inhibitors ChEBI proton pump inhibitor ChEBI proton pump inhibitors ChEBI Manual Xref Database Proton_pump_inhibitor Wikipedia View more database links Last Modified 14 July 2015