lonidamine (CHEBI:50138)

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ChEBI Name	lonidamine

ChEBI ID	CHEBI:50138

Definition	A member of the class of indazoles that is 1H-indazole that is substituted at positions 1 and 3 by 2,4-dichlorobenzyl and carboxy groups, respectively.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C15H10Cl2N2O2

Net Charge

Average Mass

321.15758

Monoisotopic Mass

320.01193

InChI

InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21)

InChIKey

WDRYRZXSPDWGEB-UHFFFAOYSA-N

SMILES

OC(=O)c1nn(Cc2ccc(Cl)cc2Cl)c2ccccc12

Roles Classification
Chemical Role(s):	Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). (via oxoacid )

Biological Role(s):	EC 2.7.1.1 (hexokinase) inhibitor An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of hexokinase, EC 2.7.1.1, an enzyme that phosphorylates hexoses forming hexose phosphate.

Application(s):	geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. antispermatogenic agent An agent that destroy spermatozoa in the male genitalia and block spermatogenesis. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	lonidamine (CHEBI:50138) has role antineoplastic agent (CHEBI:35610) lonidamine (CHEBI:50138) has role antispermatogenic agent (CHEBI:145047) lonidamine (CHEBI:50138) has role EC 2.7.1.1 (hexokinase) inhibitor (CHEBI:78366) lonidamine (CHEBI:50138) has role geroprotector (CHEBI:176497) lonidamine (CHEBI:50138) is a dichlorobenzene (CHEBI:23697) lonidamine (CHEBI:50138) is a indazoles (CHEBI:38769) lonidamine (CHEBI:50138) is a monocarboxylic acid (CHEBI:25384)

Incoming	gamendazole (CHEBI:90703) has functional parent lonidamine (CHEBI:50138)

IUPAC Name

1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid

Synonyms	Sources
1-(2,4-dichlorbenzyl)-indazole-3-carboxylic acid	ChemIDplus
DICA	ChemIDplus
diclondazolic acid	ChemIDplus
Lonidamin	ChEBI

Brand Name	Source
Doridamina	ChemIDplus

Last Modified

26 October 2021