levosimendan (CHEBI:50567)

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ChEBI Name	levosimendan

ChEBI ID	CHEBI:50567

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C14H12N6O

Net Charge

Average Mass

280.28492

Monoisotopic Mass

280.10726

InChI

InChI=1S/C14H12N6O/c1-9-6-13(21)19-20-14(9)10-2-4-11(5-3-10)17-18-12(7-15)8-16/h2-5,9,17H,6H2,1H3,(H,19,21)/t9-/m1/s1

InChIKey

WHXMKTBCFHIYNQ-SECBINFHSA-N

SMILES

C[C@@H]1CC(=O)NN=C1c1ccc(NN=C(C#N)C#N)cc1

Roles Classification
Biological Role(s):	EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor which interferes with the action of 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17).

Application(s):	cardiotonic drug A drug that has a strengthening effect on the heart or that can increase cardiac output. vasodilator agent A drug used to cause dilation of the blood vessels. anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.

ChEBI Ontology
Outgoing	levosimendan (CHEBI:50567) has role anti-arrhythmia drug (CHEBI:38070) levosimendan (CHEBI:50567) has role cardiotonic drug (CHEBI:38147) levosimendan (CHEBI:50567) has role EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor (CHEBI:50568) levosimendan (CHEBI:50567) has role vasodilator agent (CHEBI:35620) levosimendan (CHEBI:50567) is a hydrazone (CHEBI:38532) levosimendan (CHEBI:50567) is a nitrile (CHEBI:18379) levosimendan (CHEBI:50567) is a pyridazinone (CHEBI:26414)

IUPAC Name

({4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl]phenyl}hydrazono)propanedintrile

Brand Name	Source
Simdax	DrugBank

Last Modified

22 February 2017