CHEBI:5062 - finasteride

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name finasteride
ChEBI ID CHEBI:5062
Definition An aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
more structures >>
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C23H36N2O2
Net Charge 0
Average Mass 372.545
Monoisotopic Mass 372.27768
InChI InChI=1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
InChIKey DBEPLOCGEIEOCV-WSBQPABSSA-N
SMILES C1=CC(N[C@]2([C@]1([C@@]3([C@@](CC2)([C@]4([C@](CC3)([C@](CC4)(C(NC(C)(C)C)=O)[H])C)[H])[H])[H])C)[H])=O
Roles Classification
Biological Role(s): EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor
An EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of of 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+), EC 1.3.1.22, the enzyme which converts testosterone (CHEBI:17347) into the more potent androgen 5alpha-dihydrotestosterone.
androgen antagonist
A compound which inhibits or antagonises the biosynthesis or actions of androgens.
Application(s): antihyperplasia drug
A drug used for the treatment of hyperplasia (increaced cell production within an organ or tissue).
androgen antagonist
A compound which inhibits or antagonises the biosynthesis or actions of androgens.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing finasteride (CHEBI:5062) has parent hydride 5α-androstane (CHEBI:28859)
finasteride (CHEBI:5062) has role androgen antagonist (CHEBI:35497)
finasteride (CHEBI:5062) has role antihyperplasia drug (CHEBI:59844)
finasteride (CHEBI:5062) has role EC 1.3.1.22 [3-oxo-5α-steroid 4-dehydrogenase (NADP+)] inhibitor (CHEBI:50781)
finasteride (CHEBI:5062) is a δ-lactam (CHEBI:77727)
finasteride (CHEBI:5062) is a 3-oxo steroid (CHEBI:47788)
finasteride (CHEBI:5062) is a aza-steroid (CHEBI:35726)
IUPAC Name
N-tert-butyl-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide
INNs Sources
finasterida DrugBank
finasteride KEGG DRUG
finasteridum DrugBank
Synonym Source
(5alpha,17beta)-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide ChemIDplus
Manual Xrefs Databases
1171 DrugCentral
D00321 KEGG DRUG
DB01216 DrugBank
EP155096 Patent
Finasteride Wikipedia
HMDB0001984 HMDB
LSM-1999 LINCS
US4760071 Patent
View more database links
Registry Numbers Types Sources
4269024 Reaxys Registry Number Reaxys
4269024 Beilstein Registry Number Beilstein
98319-26-7 CAS Registry Number ChemIDplus
98319-26-7 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
15956333 PubMed citation Europe PMC
23552442 PubMed citation Europe PMC
Last Modified
10 May 2018