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Montelukast, sold under the brand name Singulair among others, is a medication used in the maintenance treatment of asthma. It is generally less preferred for this use than inhaled corticosteroids. It is not useful for acute asthma attacks. Other uses include allergic rhinitis and hives of long duration. For allergic rhinitis it is a second-line treatment.
Common side effects include abdominal pain, cough, and headache. Severe side effects may include allergic reactions, such as anaphylaxis and eosinophilia. Use in pregnancy appears to be safe. Montelukast is in the leukotriene receptor antagonist family of medications. It works by blocking the action of leukotriene D4 in the lungs resulting in decreased inflammation and relaxation of smooth muscle.
Montelukast was approved for medical use in the United States in 1998. It is available as a generic medication. In 2022, it was the seventeenth most commonly prescribed medication in the United States, with more than 29 million prescriptions. |
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CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC1)CC(O)=O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1 |
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Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
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leukotriene antagonist
A drug designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
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anti-arrhythmia drug
A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
anti-asthmatic drug
A drug used to treat asthma.
leukotriene antagonist
A drug designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
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View more via ChEBI Ontology
{1- [({(1R)- 1- {3- [(E)- 2- (7- chloroquinolin- 2- yl)ethenyl]phenyl}- 3- [2- (2- hydroxypropan- 2- yl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid
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(R- (E))- 1- (((1- (3- (2- (7- Chloro- 2- quinolinyl)ethenyl)phenyl)- 3- (2- (1- hydroxy- 1- methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid
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ChemIDplus
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1- [[[(1 R)- 1- [3- [(1E)- 2- (7- chloro- 2- quinolinyl)ethenyl] phenyl]- 3- [2- (1- hydroxy- 1- methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid
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Patent
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Montelukast
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KEGG COMPOUND
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MONTELUKAST
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PDBeChem
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1836
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DrugCentral
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C07482
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KEGG COMPOUND
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D08229
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KEGG DRUG
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DB00471
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DrugBank
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EP1886997
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Patent
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Montelukast
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Wikipedia
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MTK
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PDBeChem
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View more database links |
158966-92-8
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CAS Registry Number
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KEGG COMPOUND
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158966-92-8
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CAS Registry Number
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ChemIDplus
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7896575
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Beilstein Registry Number
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Beilstein
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