aceprometazine (CHEBI:53770)

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ChEBI Name	aceprometazine

ChEBI ID	CHEBI:53770

Definition	A phenothiazine compound having an acetyl group at the 2-position and a 2-(dimethylamino)-1-propyl group at the 10-position.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information	ChemicalBook:CB3149595, eMolecules:567788

Download	Molfile XML SDF

Wikipedia	License
Stercobilinogen (fecal urobilinogen) is a chemical created by bacteria in the gut. It is made of broken-down hemoglobin. It is further processed to become the chemical that gives feces its brown color. Bilirubin is a pigment that results from the breakdown of the heme portion of hemoglobin. The liver conjugates bilirubin, making it water-soluble; and the conjugated form is then excreted in urine as urobilinogen and in the feces as stercobilinogen. Urobilinogen / stercobilinogen is colourless and is further oxidised to stercobilin which imparts colour to feces. Darkening of feces upon standing in air is due to the oxidation of residual urobilinogens to urobilins. In the intestine, bilirubin is converted by bacteria to stercobilinogen. Stercobilinogen is absorbed and excreted by either the liver or the kidney.
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Formula

C19H22N2OS

Net Charge

Average Mass

326.45600

Monoisotopic Mass

326.14528

InChI

InChI=1S/C19H22N2OS/c1-13(20(3)4)12-21-16-7-5-6-8-18(16)23-19-10-9-15(14(2)22)11-17(19)21/h5-11,13H,12H2,1-4H3

InChIKey

XLOQNFNTQIRSOX-UHFFFAOYSA-N

SMILES

CC(CN1c2ccccc2Sc2ccc(cc12)C(C)=O)N(C)C

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	histamine antagonist Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.

Application(s):	anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. sedative A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. histamine antagonist Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.

ChEBI Ontology
Outgoing	aceprometazine (CHEBI:53770) has role anxiolytic drug (CHEBI:35474) aceprometazine (CHEBI:53770) has role histamine antagonist (CHEBI:37956) aceprometazine (CHEBI:53770) has role sedative (CHEBI:35717) aceprometazine (CHEBI:53770) is a aromatic ketone (CHEBI:76224) aceprometazine (CHEBI:53770) is a methyl ketone (CHEBI:51867) aceprometazine (CHEBI:53770) is a phenothiazines (CHEBI:38093) aceprometazine (CHEBI:53770) is a tertiary amine (CHEBI:32876)

Incoming	(R)-aceprometazine (CHEBI:53771) is a aceprometazine (CHEBI:53770) (S)-aceprometazine (CHEBI:53772) is a aceprometazine (CHEBI:53770)

IUPAC Name

1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethanone

Synonyms	Sources
10-(2-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketone	ChEBI
Acepromethazine	ChemIDplus

Last Modified

22 February 2017