hydrochlorothiazide (CHEBI:5778)

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ChEBI Name	hydrochlorothiazide

ChEBI ID	CHEBI:5778

Definition	A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information	ChemicalBook:CB4294102, eMolecules:494771, ZINC000062233929

Download	Molfile XML SDF

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Formula

C7H8ClN3O4S2

Net Charge

Average Mass

297.73900

Monoisotopic Mass

296.96448

InChI

InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

InChIKey

JZUFKLXOESDKRF-UHFFFAOYSA-N

SMILES

NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl

Roles Classification
Chemical Role(s):	environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects.

Biological Role(s):	xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.

Application(s):	diuretic An agent that promotes the excretion of urine through its effects on kidney function. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.

ChEBI Ontology
Outgoing	hydrochlorothiazide (CHEBI:5778) has role antihypertensive agent (CHEBI:35674) hydrochlorothiazide (CHEBI:5778) has role diuretic (CHEBI:35498) hydrochlorothiazide (CHEBI:5778) has role environmental contaminant (CHEBI:78298) hydrochlorothiazide (CHEBI:5778) has role xenobiotic (CHEBI:35703) hydrochlorothiazide (CHEBI:5778) is a benzothiadiazine (CHEBI:50265) hydrochlorothiazide (CHEBI:5778) is a organochlorine compound (CHEBI:36683) hydrochlorothiazide (CHEBI:5778) is a sulfonamide (CHEBI:35358)

IUPAC Name

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Synonym	Source
Esidrix (TN)	KEGG COMPOUND

Last Modified

22 February 2017