CHEBI:59045 - α-L-Fucp-(1→2)-β-D-Galp-(1→4)-[α-L-Fucp-(1→3)]-β-D-GlcpNAc

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name α-L-Fucp-(1→2)-β-D-Galp-(1→4)-[α-L-Fucp-(1→3)]-β-D-GlcpNAc
ChEBI ID CHEBI:59045
ChEBI ASCII Name alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc
Definition A branched amino tetrasaccharide consisting of N-acetyl-β-D-glucosamine at the reducing end having an α-L-fucosyl residue attached at the 3-position and an α-L-fucosyl-(1→2)-β-D-galactosyl moiety attached at the 4-position. A cancer-associated tetrasaccharide antigen which constitutes the core structure recognised by therapeutic antibody BR96. Conformational restriction around the GlcNAc residue is a key feature of its structure.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:60518
Supplier Information
Download Molfile XML SDF
Formula C26H45NO19
Net Charge 0
Average Mass 675.63080
Monoisotopic Mass 675.25858
InChI InChI=1S/C26H45NO19/c1-6-12(31)15(34)18(37)24(40-6)45-21-11(27-8(3)30)23(39)42-10(5-29)20(21)44-26-22(17(36)14(33)9(4-28)43-26)46-25-19(38)16(35)13(32)7(2)41-25/h6-7,9-26,28-29,31-39H,4-5H2,1-3H3,(H,27,30)/t6-,7-,9+,10+,11+,12+,13+,14-,15+,16+,17-,18-,19-,20+,21+,22+,23+,24-,25-,26-/m0/s1
InChIKey SRHNADOZAAWYLV-XLMUYGLTSA-N
SMILES C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]2O[C@@H]2[C@@H](CO)O[C@@H](O)[C@H](NC(C)=O)[C@H]2O[C@@H]2O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)[C@@H](O)[C@H](O)[C@@H]1O
Roles Classification
Biological Role(s): epitope
The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.
antigen
Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC).
(via alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-D-GlcpNAc )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing α-L-Fucp-(1→2)-β-D-Galp-(1→4)-[α-L-Fucp-(1→3)]-β-D-GlcpNAc (CHEBI:59045) has role antigen (CHEBI:59132)
α-L-Fucp-(1→2)-β-D-Galp-(1→4)-[α-L-Fucp-(1→3)]-β-D-GlcpNAc (CHEBI:59045) has role epitope (CHEBI:53000)
α-L-Fucp-(1→2)-β-D-Galp-(1→4)-[α-L-Fucp-(1→3)]-β-D-GlcpNAc (CHEBI:59045) is a α-L-Fucp-(1→2)-β-D-Galp-(1→4)-[α-L-Fucp-(1→3)]-D-GlcpNAc (CHEBI:62507)
Incoming α-L-Fucp-(1→2)-β-D-Galp-(1→4)-[α-L-Fucp-(1→3)]-β-D-GlcpNAc-yl group (CHEBI:88162) is substituent group from α-L-Fucp-(1→2)-β-D-Galp-(1→4)-[α-L-Fucp-(1→3)]-β-D-GlcpNAc (CHEBI:59045)
IUPAC Name
α-L-fucopyranosyl-(1→3)-[α-L-fucopyranosyl-(1→2)-β-D-galactopyranosyl-(1→4)]-2-acetamido-2-deoxy-β-D-glucopyranose
Synonyms Sources
6-deoxy-α-L-galactopyranosyl-(1→3)-[6-deoxy-α-L-galactopyranosyl-(1→2)-β-D-galactopyranosyl-(1→4)]-2-acetamido-2-deoxy-β-D-glucopyranose IUPAC
α-Fuc-(1→2)-β-Gal-(1→4)-[α-Fuc-(1→3)]-β-GlcNAc ChEBI
α-L-Fuc-(1→2)-β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-β-D-GlcNAc ChEBI
α-L-fucopyranosyl-(1→2)-β-D-galactopyranosyl-(1→4)-[α-L-fucopyranosyl-(1→3)]-2-acetamido-2-deoxy-β-D-glucopyranose ChEBI
α-L-fucosyl-(1→2)-β-D-galactosyl-(1→4)-[α-L-fucosyl-(1→3)]-N-acetyl-β-D-glucosamine ChEBI
β-D-glucopyranose, O-6-deoxy-α-L-galactopyranosyl-(1→3)-O-[O-6-deoxy-α-L-galactopyranosyl-(1→2)-β-D-galactopyranosyl-(1→4)]-2-(acetylamino)-2-deoxy- ChEBI
Fuca1-2Galb1-4(Fuca1-3)GlcNAcb ChEBI
Fucα1-2Galβ1-4(Fucα1-3)GlcNAc ChEBI
Fucα1-2Galβ1-4(Fucα1-3)GlcNAcβ ChEBI
Fucα1-3(Fucα1-2Galβ1-4)GclNAc ChEBI
Lewis Y ChEBI
Lewis Y tetrasaccharide ChEBI
Ley ChEBI
O-6-deoxy-α-L-galactopyranosyl-(1→3)-O-[O-6-deoxy-α-L-galactopyranosyl-(1→2)-β-D-galactopyranosyl-(1→4)]-2-(acetylamino)-2-deoxy-β-D-glucopyranose ChEBI
WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5][a2112h-1b_1-5]/1-2-3-2/a3-b1_a4-c1_c2-d1 GlyTouCan
Manual Xrefs Databases
G00052MO GlyGen
G00052MO GlyTouCan
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Last Modified
27 April 2024