CHEBI:59119 - thiopropazate

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ChEBI Name thiopropazate
ChEBI ID CHEBI:59119
Definition A phenothiazine derivative in which 10H-phenothiazine has a chloro subsitituent at the 2-position and a 3-[4-(2-acetoxyethyl)piperazin-1-yl]propyl group at N-10.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information ZINC000022446680
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Formula C23H28ClN3O2S
Net Charge 0
Average Mass 446.00500
Monoisotopic Mass 445.15908
InChI InChI=1S/C23H28ClN3O2S/c1-18(28)29-16-15-26-13-11-25(12-14-26)9-4-10-27-20-5-2-3-6-22(20)30-23-8-7-19(24)17-21(23)27/h2-3,5-8,17H,4,9-16H2,1H3
InChIKey AIUHRQHVWSUTGJ-UHFFFAOYSA-N
SMILES CC(=O)OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc23)CC1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
Application(s): phenothiazine antipsychotic drug

dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
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ChEBI Ontology
Outgoing thiopropazate (CHEBI:59119) has role dopaminergic antagonist (CHEBI:48561)
thiopropazate (CHEBI:59119) has role phenothiazine antipsychotic drug (CHEBI:37930)
thiopropazate (CHEBI:59119) is a N-alkylpiperazine (CHEBI:46845)
thiopropazate (CHEBI:59119) is a acetate ester (CHEBI:47622)
thiopropazate (CHEBI:59119) is a organochlorine compound (CHEBI:36683)
thiopropazate (CHEBI:59119) is a phenothiazines (CHEBI:38093)
IUPAC Name
2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethyl acetate
INNs Sources
thiopropazate KEGG DRUG
thiopropazatum ChemIDplus
tiopropazato ChemIDplus
Synonyms Sources
1-(2-Acetoxyethyl)-4-(3-(2-chloro-10-phenothiazinyl)propyl)piperazine ChemIDplus
10-(3-(1-(2-Acetoxyethyl)-4-piperazinyl)propyl)-2-chlorophenothiazine ChemIDplus
2-(4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethyl acetate NIST Chemistry WebBook
2-Chloro-10-(3-(1-(2-acetoxyethyl)-4-piperazinyl)propyl)phenothiazine ChemIDplus
4-(3-(2-Chlorophenothiazin-10-yl)propyl)-1-piperazineethanol acetate NIST Chemistry WebBook
N-(beta-Acetoxyethyl)-N'-(gamma-(2'-chloro-10'-phenothiazinyl)propyl)piperazine ChemIDplus
Thiopropazat ChemIDplus
Manual Xrefs Databases
2634 DrugCentral
D09216 KEGG DRUG
Thiopropazate Wikipedia
US2766235 Patent
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Registry Numbers Types Sources
770207 Reaxys Registry Number Reaxys
84-06-0 CAS Registry Number ChemIDplus
84-06-0 CAS Registry Number NIST Chemistry WebBook
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Last Modified
22 February 2017