CHEBI:59587 - disodium clodronate tetrahydrate

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ChEBI Name disodium clodronate tetrahydrate
ChEBI ID CHEBI:59587
Definition The tetrahydrate of the disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula CH10Cl2Na2O10P2
Net Charge 0
Average Mass 360.91700
Monoisotopic Mass 359.89216
InChI InChI=1S/CH4Cl2O6P2.2Na.4H2O/c2-1(3,10(4,5)6)11(7,8)9;;;;;;/h(H2,4,5,6)(H2,7,8,9);;;4*1H2/q;2*+1;;;;/p-2
InChIKey XWHPUCFOTRBMGS-UHFFFAOYSA-L
SMILES O.O.O.O.[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O
Roles Classification
Application(s): bone density conservation agent
An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
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ChEBI Ontology
Outgoing disodium clodronate tetrahydrate (CHEBI:59587) has part clodronic acid disodium salt (CHEBI:59586)
disodium clodronate tetrahydrate (CHEBI:59587) has role bone density conservation agent (CHEBI:50646)
disodium clodronate tetrahydrate (CHEBI:59587) is a hydrate (CHEBI:35505)
disodium clodronate tetrahydrate (CHEBI:59587) is a one-carbon compound (CHEBI:64708)
IUPAC Name
disodium (dichloromethanediyl)bis[hydrogen (phosphonate)]—water (1/4)
Synonyms Sources
clodronate disodium ChEBI
clodronate disodium tetrahydrate ChEBI
disodium (dichloromethylene)disphosphonate tetrahydrate ChEBI
Last Modified
12 June 2012