CHEBI:59750 - diflorasone

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ChEBI Name diflorasone
ChEBI ID CHEBI:59750
Definition The 16β-analogue of flumethasone. It is used as the 17,21-diacetate as a topical anti-inflammatory and antipruritic in the treatment of various skin disorders.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C22H28F2O5
Net Charge 0
Average Mass 410.45150
Monoisotopic Mass 410.19048
InChI InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1
InChIKey WXURHACBFYSXBI-XHIJKXOTSA-N
SMILES [H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
Roles Classification
Biological Role(s): hormone
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
(via steroid hormone )
Application(s): anti-inflammatory drug
A substance that reduces or suppresses inflammation.
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ChEBI Ontology
Outgoing diflorasone (CHEBI:59750) has parent hydride pregnane (CHEBI:8386)
diflorasone (CHEBI:59750) has role anti-inflammatory drug (CHEBI:35472)
diflorasone (CHEBI:59750) is a 11β-hydroxy steroid (CHEBI:35346)
diflorasone (CHEBI:59750) is a 17α-hydroxy steroid (CHEBI:35342)
diflorasone (CHEBI:59750) is a 20-oxo steroid (CHEBI:36885)
diflorasone (CHEBI:59750) is a 21-hydroxy steroid (CHEBI:35344)
diflorasone (CHEBI:59750) is a 3-oxo-Δ1,Δ4-steroid (CHEBI:77166)
diflorasone (CHEBI:59750) is a fluorinated steroid (CHEBI:50830)
diflorasone (CHEBI:59750) is a glucocorticoid (CHEBI:24261)
diflorasone (CHEBI:59750) is a primary α-hydroxy ketone (CHEBI:139590)
diflorasone (CHEBI:59750) is a tertiary α-hydroxy ketone (CHEBI:139592)
Incoming diflorasone diacetate (CHEBI:31483) has functional parent diflorasone (CHEBI:59750)
IUPAC Name
6α,9-difluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione
INNs Sources
diflorasona ChemIDplus
diflorasone ChemIDplus
diflorasonum ChemIDplus
Synonym Source
(6α,11β,16β)-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione ChEBI
Manual Xrefs Databases
D07827 KEGG DRUG
DB00223 DrugBank
Diflorasone Wikipedia
GB881334 Patent
GB898293 Patent
GB912015 Patent
US3557158 Patent
View more database links
Registry Numbers Types Sources
2557-49-5 CAS Registry Number KEGG DRUG
2557-49-5 CAS Registry Number ChemIDplus
5645455 Beilstein Registry Number Beilstein
Last Modified
07 February 2018