EC 3.5.1.98 (histone deacetylase) inhibitor |
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CHEBI:61115 |
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An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98). |
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This entity has been manually annotated by the ChEBI Team.
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Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases. Since deacetylation of histones produces transcriptionally silenced heterochromatin, HDIs can render chromatin more transcriptionally active and induce epigenomic changes.
HDIs have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptics, such as valproic acid. Since at least 2003 they have been investigated as possible treatments for cancers, parasitic and inflammatory diseases.
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EC 3.5.1.98 (histone deacetylase) inhibitors
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ChEBI
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EC 3.5.1.98 inhibitor
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ChEBI
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EC 3.5.1.98 inhibitors
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ChEBI
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HDAC inhibitor
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ChEBI
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HDAC inhibitors
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ChEBI
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HDACi
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ChEBI
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HDACis
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ChEBI
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HDI
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ChEBI
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HDIs
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ChEBI
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histone amidohydrolase inhibitor
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ChEBI
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histone amidohydrolase inhibitors
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ChEBI
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histone deacetylase (EC 3.5.1.98) inhibitor
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ChEBI
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histone deacetylase (EC 3.5.1.98) inhibitors
|
ChEBI
|
histone deacetylase inhibitor
|
ChEBI
|
histone deacetylase inhibitors
|
ChEBI
|
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