CHEBI:61115 - EC 3.5.1.98 (histone deacetylase) inhibitor

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ChEBI Name EC 3.5.1.98 (histone deacetylase) inhibitor
ChEBI ID CHEBI:61115
Definition An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
Stars This entity has been manually annotated by the ChEBI Team.
Wikipedia License
Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases. Since deacetylation of histones produces transcriptionally silenced heterochromatin, HDIs can render chromatin more transcriptionally active and induce epigenomic changes. HDIs have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptics, such as valproic acid. Since at least 2003 they have been investigated as possible treatments for cancers, parasitic and inflammatory diseases.
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ChEBI Ontology
Outgoing EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115) is a EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor (CHEBI:76807)
Incoming 3',4'-dihydroxyaurone (CHEBI:144745) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide (CHEBI:125562) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
4-phenylbutyric acid (CHEBI:41500) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
N-hydroxy-7-(naphthalen-2-ylthio)heptanamide (CHEBI:94741) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
abexinostat (CHEBI:92223) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
AR-42 (CHEBI:188197) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
belinostat (CHEBI:61076) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
bis-(4-hydroxybenzyl)sulfide (CHEBI:65500) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
BML-210 (CHEBI:61077) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
BPDZ 711 (CHEBI:138512) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
butyrate (CHEBI:17968) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
caffeic acid (CHEBI:36281) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
carbamazepine (CHEBI:3387) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
CG-1521 (CHEBI:156510) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
CHIC-35 (CHEBI:142489) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
curcumin (CHEBI:3962) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
depudecin (CHEBI:64143) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
entinostat (CHEBI:132082) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
givinostat (CHEBI:94187) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
givinostat hydrochloride (CHEBI:231333) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
givinostat hydrochloride monohydrate (CHEBI:231335) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
HC toxin (CHEBI:48028) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
MC1568 (CHEBI:140475) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
methylseleninic acid (CHEBI:77012) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
MIND4 (CHEBI:232555) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
mocetinostat (CHEBI:197437) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
nicotinamide (CHEBI:17154) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
panobinostat (CHEBI:85990) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
panobinostat lactate (CHEBI:85991) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
pracinostat (CHEBI:95071) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
pyridin-3-ylmethyl {4-[(2-amino-4-fluorophenyl)carbamoyl]benzyl}carbamate (CHEBI:125311) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
quisinostat (CHEBI:94771) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
resminostat (CHEBI:231352) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
RG-2833 (CHEBI:233052) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
RGFP966 (CHEBI:131163) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
ricolinostat (CHEBI:95073) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
romidepsin (CHEBI:61080) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
sirtinol (CHEBI:73158) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
sodium butyrate (CHEBI:64103) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
sodium phenylbutyrate (CHEBI:75316) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
sodium valproate (CHEBI:9925) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
spiruchostatin B (CHEBI:90235) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
sulforaphane (CHEBI:47807) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
tacedinaline (CHEBI:90195) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
trapoxin A (CHEBI:84057) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
tributyrin (CHEBI:35020) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
trichostatin A (CHEBI:46024) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
tubastatin A (CHEBI:94186) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
valproic acid (CHEBI:39867) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
vorinostat (CHEBI:45716) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
Sir1 inhibitor (CHEBI:90375) is a EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
Sir2 inhibitor (CHEBI:71181) is a EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
Synonyms Sources
EC 3.5.1.98 (histone deacetylase) inhibitors ChEBI
EC 3.5.1.98 inhibitor ChEBI
EC 3.5.1.98 inhibitors ChEBI
HDAC inhibitor ChEBI
HDAC inhibitors ChEBI
HDACi ChEBI
HDACis ChEBI
HDI ChEBI
HDIs ChEBI
histone amidohydrolase inhibitor ChEBI
histone amidohydrolase inhibitors ChEBI
histone deacetylase (EC 3.5.1.98) inhibitor ChEBI
histone deacetylase (EC 3.5.1.98) inhibitors ChEBI
histone deacetylase inhibitor ChEBI
histone deacetylase inhibitors ChEBI
Manual Xref Database
Histone_deacetylase_inhibitor Wikipedia
View more database links
Last Modified
03 February 2025