| Ketorolac, sold under the brand name Toradol, Acular and Sprix, among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain. Specifically it is recommended for moderate to severe pain. Recommended duration of treatment is less than six days, and in Switzerland not more than seven days (parenterally two days). It is used by mouth, by nose, by injection into a vein or muscle, and as eye drops. Effects begin within an hour and last for up to eight hours. Ketorolac also has antipyretic (fever-reducing) properties.
Common side effects include sleepiness, dizziness, abdominal pain, swelling, and nausea. Serious side effects may include stomach bleeding, kidney failure, heart attacks, bronchospasm, heart failure, and anaphylaxis. Use is not recommended during the last part of pregnancy or during breastfeeding. Ketorolac works by blocking cyclooxygenase 1 and 2 (COX1 and COX2), thereby decreasing production of prostaglandins.
Ketorolac was patented in 1976 and approved for medical use in 1989. It is available as a generic medication. In 2022, it was the 223rd most commonly prescribed medication in the United States, with more than 1 million prescriptions.
Due to a series of deaths due to gastrointestinal bleeding and kidney failure, ketorolac as a pain medication was removed from the German market in 1993. When ketorolac was introduced into Germany, it was often used as an opioid replacement in pain therapy because its side effects were perceived as much less severe, it did not produce any dependence, and a dose was effective for 7–8 hours compared to morphine with 3–4 hours. As a very potent prostaglandin inhibitor, ketorolac diminishes the kidney's own defenses against vasoconstriction-related effects, e.g. during blood loss or high endogenous catecholamine levels.
|
|
Read full article at Wikipedia
|
InChI=1S/C15H13NO3/c17- 14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19) |
| OZWKMVRBQXNZKK-UHFFFAOYSA-N |
| N12C(C(C(=O)O)CC1)=CC=C2C(=O)C3=CC=CC=C3 |
|
|
cyclooxygenase 2 inhibitor
A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
cyclooxygenase 1 inhibitor
A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.
analgesic
An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
|
|
|
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
analgesic
An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
|
|
View more via ChEBI Ontology
|
rac-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
|
|
ketorolac
|
ChemIDplus
|
kétorolac
|
WHO MedNet
|
ketorolaco
|
ChemIDplus
|
ketorolacum
|
ChemIDplus
|
|
(±)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
|
ChemIDplus
|
|
(±)-ketorolac
|
ChemIDplus
|
|
rac-ketorolac
|
ChEBI
|
|
413572
|
Reaxys Registry Number
|
Reaxys
|
|
74103-06-3
|
CAS Registry Number
|
KEGG COMPOUND
|
|
74103-06-3
|
CAS Registry Number
|
ChemIDplus
|
|
74103-06-3
|
CAS Registry Number
|
KEGG DRUG
|
|
2013-11-07
