CHEBI:63628 - tipranavir

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ChEBI Name tipranavir
ChEBI ID CHEBI:63628
Definition A pyridine-2-sulfonamide substituted at C-5 by a trifluoromethyl group and at the sulfonamide nitrogen by a dihydropyrone-containing m-tolyl substituent. It is an HIV-1 protease inhibitor.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Anonymous
Supplier Information
Download Molfile XML SDF
Formula C31H33F3N2O5S
Net Charge 0
Average Mass 602.66400
Monoisotopic Mass 602.20623
InChI InChI=1S/C31H33F3N2O5S/c1-3-16-30(17-15-21-9-6-5-7-10-21)19-26(37)28(29(38)41-30)25(4-2)22-11-8-12-24(18-22)36-42(39,40)27-14-13-23(20-35-27)31(32,33)34/h5-14,18,20,25,36-37H,3-4,15-17,19H2,1-2H3/t25-,30-/m1/s1
InChIKey SUJUHGSWHZTSEU-FYBSXPHGSA-N
SMILES CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(cn3)C(F)(F)F)c2)C(=O)O1
Roles Classification
Biological Role(s): HIV protease inhibitor
An inhibitor of HIV protease, an enzyme required for production of proteins needed for viral assembly.
antiviral drug
A substance used in the prophylaxis or therapy of virus diseases.
Application(s): antiviral drug
A substance used in the prophylaxis or therapy of virus diseases.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing tipranavir (CHEBI:63628) has role antiviral drug (CHEBI:36044)
tipranavir (CHEBI:63628) has role HIV protease inhibitor (CHEBI:35660)
tipranavir (CHEBI:63628) is a sulfonamide (CHEBI:35358)
IUPAC Name
N-(3-{(1R)-1-[(6R)-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-5,6-dihydro-2H-pyran-3-yl]propyl}phenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide
INN Source
tipranavir ChemIDplus
Synonym Source
3'-((1R)-1-((6R)-5,6-Dihydro-4-hydroxy-2-oxo-6-phenethyl-6-propyl-2H-pyran-3-yl)propyl)-5-(trifluoromethyl)-2-pyridinesulfonanilide ChemIDplus
Manual Xrefs Databases
D08605 KEGG DRUG
DB00932 DrugBank
View more database links
Registry Numbers Types Sources
174484-41-4 CAS Registry Number ChemIDplus
7698323 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
17620375 PubMed citation Europe PMC
20368406 PubMed citation Europe PMC
21041916 PubMed citation Europe PMC
21571982 PubMed citation Europe PMC
21576452 PubMed citation Europe PMC
21825300 PubMed citation Europe PMC
21871444 PubMed citation Europe PMC
22007990 PubMed citation Europe PMC
22096044 PubMed citation Europe PMC
22258921 PubMed citation Europe PMC
25017682 PubMed citation Europe PMC
Last Modified
16 September 2014