CHEBI:63629 - tizanidine

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name tizanidine
ChEBI ID CHEBI:63629
Definition 2,1,3-Benzothiadiazole substituted at C-4 by a Δ1-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at α2-adrenergic receptor sites.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Anonymous
Secondary ChEBI IDs CHEBI:9608
Supplier Information
Download Molfile XML SDF
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C9H8ClN5S
Net Charge 0
Average Mass 253.71100
Monoisotopic Mass 253.01889
InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
InChIKey XFYDIVBRZNQMJC-UHFFFAOYSA-N
SMILES Clc1ccc2nsnc2c1NC1=NCCN1
Roles Classification
Biological Role(s): alpha-adrenergic agonist
An agent that selectively binds to and activates alpha-adrenergic receptors.
Application(s): alpha-adrenergic agonist
An agent that selectively binds to and activates alpha-adrenergic receptors.
muscle relaxant
A drug used to produce muscle relaxation (excepting neuromuscular blocking agents). Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. Also used for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing tizanidine (CHEBI:63629) has role α-adrenergic agonist (CHEBI:35569)
tizanidine (CHEBI:63629) has role muscle relaxant (CHEBI:51371)
tizanidine (CHEBI:63629) is a benzothiadiazole (CHEBI:48864)
tizanidine (CHEBI:63629) is a imidazoles (CHEBI:24780)
IUPAC Name
5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
INNs Sources
tizanidina ChemIDplus
tizanidine ChemIDplus
tizanidinum ChemIDplus
Synonyms Sources
5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole ChemIDplus
Tizanidine KEGG COMPOUND
Manual Xrefs Databases
2683 DrugCentral
C07452 KEGG COMPOUND
D08611 KEGG DRUG
DB00697 DrugBank
LSM-5242 LINCS
Tizanidine Wikipedia
US3843668 Patent
View more database links
Registry Numbers Types Sources
51322-75-9 CAS Registry Number KEGG COMPOUND
51322-75-9 CAS Registry Number ChemIDplus
618691 Beilstein Registry Number ChemIDplus
618691 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
21317414 PubMed citation Europe PMC
21733633 PubMed citation Europe PMC
21982341 PubMed citation Europe PMC
22196407 PubMed citation Europe PMC
22223284 PubMed citation Europe PMC
Last Modified
22 February 2017