CHEBI:64156 - imetit

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ChEBI Name imetit ChEBI ID CHEBI:64156 Definition An imidothiocarbamic ester that consists of isothiourea in which the thiol hydrogen is substituted by a 2-(imidazol-4-yl)ethyl group. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration. Stars This entity has been manually annotated by the ChEBI Team. Supplier Information Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Wikipedia License Read full article at Wikipedia Formula C6H10N4S Net Charge 0 Average Mass 170.23500 Monoisotopic Mass 170.06262 InChI InChI=1S/C6H10N4S/c7-6(8)11-2-1-5-3-9-4-10-5/h3-4H,1-2H2,(H3,7,8)(H,9,10) InChIKey PEHSVUKQDJULKE-UHFFFAOYSA-N SMILES NC(=N)SCCc1c[nH]cn1 Roles Classification Biological Role(s): H3-receptor agonist A histamine agonist that binds to and activates histamine H3-receptors. H4-receptor agonist A histamine agonist that binds to and activates H4-receptors. Application(s): H3-receptor agonist A histamine agonist that binds to and activates histamine H3-receptors. H4-receptor agonist A histamine agonist that binds to and activates H4-receptors. View more via ChEBI Ontology ChEBI Ontology Outgoing imetit (CHEBI:64156) has role H3-receptor agonist (CHEBI:64154) imetit (CHEBI:64156) has role H4-receptor agonist (CHEBI:64155) imetit (CHEBI:64156) is a imidazoles (CHEBI:24780) imetit (CHEBI:64156) is a imidothiocarbamic ester (CHEBI:38914) imetit (CHEBI:64156) is conjugate base of imetit(2+) (CHEBI:64157) Incoming imetit(2+) (CHEBI:64157) is conjugate acid of imetit (CHEBI:64156) IUPAC Name 2-(1H-imidazol-4-yl)ethyl carbamimidothioate Synonym Source S-(2-(4-Imidazolyl)ethyl)isothiourea ChemIDplus Manual Xrefs Databases C17931 KEGG COMPOUND Imetit Wikipedia View more database links Registry Numbers Types Sources 102203-18-9 CAS Registry Number KEGG COMPOUND 102203-18-9 CAS Registry Number ChemIDplus 880781 Reaxys Registry Number Reaxys Last Modified 12 March 2012