|
|
| dimercaprol |
|
| CHEBI:64198 |
|
| A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury. |
|
This entity has been manually annotated by the ChEBI Team.
|
|
| ChemicalBook:CB7684878, eMolecules:503400 |
|
|
Molfile
XML
SDF
|
|
|
|
|
| Dimercaprol, also called British anti-Lewisite (BAL), is a medication used to treat acute poisoning by arsenic, mercury, gold, and lead. It may also be used for antimony, thallium, or bismuth poisoning, although the evidence for those uses is not very strong. It is given by injection into a muscle.
Common side effects include high blood pressure, pain at the site of the injection, vomiting, and fever. It is not recommended for people with peanut allergies as it is typically formulated as a suspension in peanut oil. It is unclear if use in pregnancy is safe for the baby. Dimercaprol is a chelator and works by binding with heavy metals. It has a very pungent odor.
Dimercaprol was first made during World War II. It is on the World Health Organization's List of Essential Medicines. |
|
Read full article at Wikipedia
|
| InChI=1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2 |
| WQABCVAJNWAXTE-UHFFFAOYSA-N |
|
|
chelator
A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate.
|
|
View more via ChEBI Ontology
|
2,3-disulfanylpropan-1-ol
|
|
dimercaprol
|
ChemIDplus
|
dimercaprolum
|
ChemIDplus
|
|
1,2-dimercapto-3-propanol
|
ChemIDplus
|
|
1,2-dithioglycerol
|
ChemIDplus
|
|
2,3-dimercapto-1-propanol
|
ChemIDplus
|
|
2,3-Dimercapto-1-propanol
|
KEGG COMPOUND
|
|
2,3-dimercaptol-1-propanol
|
ChemIDplus
|
|
2,3-dimercaptopropanol
|
ChemIDplus
|
|
2,3-dithiopropanol
|
ChemIDplus
|
|
2,3-mercaptopropan-1-ol
|
NIST Chemistry WebBook
|
|
2,3-Mercaptopropanol
|
KEGG COMPOUND
|
|
3-hydroxy-1,2-propanedithiol
|
ChemIDplus
|
|
α,β-dithioglycerol
|
ChemIDplus
|
|
BAL
|
ChemIDplus
|
|
British anti-Lewisite
|
DrugBank
|
|
British anti-lewisite
|
KEGG COMPOUND
|
|
British antilewisite
|
ChemIDplus
|
|
dimercaptopropanol
|
ChemIDplus
|
|
dithioglycerine
|
NIST Chemistry WebBook
|
|
dithioglycerol
|
ChemIDplus
|
|
sulfactin
|
ChemIDplus
|
|
3150
|
DrugCentral
|
|
C02924
|
KEGG COMPOUND
|
|
D00167
|
KEGG DRUG
|
|
DB06782
|
DrugBank
|
|
Dimercaprol
|
Wikipedia
|
|
US2402665
|
Patent
|
| View more database links |
|
1732058
|
Reaxys Registry Number
|
Reaxys
|
|
59-52-9
|
CAS Registry Number
|
KEGG COMPOUND
|
|
59-52-9
|
CAS Registry Number
|
NIST Chemistry WebBook
|
|
59-52-9
|
CAS Registry Number
|
ChemIDplus
|
|
