CHEBI:6533 - loperamide hydrochloride

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ChEBI Name loperamide hydrochloride
ChEBI ID CHEBI:6533
Definition A hydrochloride obtained by combining loperamide with one equivalent of hydrochloric acid. Used for treatment of diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C29H34Cl2N2O2
Net Charge 0
Average Mass 513.49800
Monoisotopic Mass 512.19973
InChI InChI=1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H
InChIKey PGYPOBZJRVSMDS-UHFFFAOYSA-N
SMILES Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1
Roles Classification
Biological Role(s): anticoronaviral agent
Any antiviral agent which inhibits the activity of coronaviruses.
mu-opioid receptor agonist
A compound that exhibits agonist activity at the mu-opioid receptor.
Application(s): mu-opioid receptor agonist
A compound that exhibits agonist activity at the mu-opioid receptor.
antidiarrhoeal drug
Any drug found useful in the symptomatic treatment of diarrhoea.
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ChEBI Ontology
Outgoing loperamide hydrochloride (CHEBI:6533) has part loperamide(1+) (CHEBI:86969)
loperamide hydrochloride (CHEBI:6533) has role μ-opioid receptor agonist (CHEBI:55322)
loperamide hydrochloride (CHEBI:6533) has role anticoronaviral agent (CHEBI:149553)
loperamide hydrochloride (CHEBI:6533) has role antidiarrhoeal drug (CHEBI:55323)
loperamide hydrochloride (CHEBI:6533) is a hydrochloride (CHEBI:36807)
IUPAC Names
4-(4-chlorophenyl)-1-[4-(dimethylamino)-4-oxo-3,3-diphenylbutyl]-4-hydroxypiperidin-1-ium chloride
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride
Synonyms Sources
4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidine butyramide HCl ChemIDplus
4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutyramide monohydrochloride ChemIDplus
Imodium ChemIDplus
Loperamide HCl ChemIDplus
Manual Xrefs Databases
D00729 KEGG DRUG
DB00836 DrugBank
View more database links
Registry Numbers Types Sources
34552-83-5 CAS Registry Number ChemIDplus
4087090 Reaxys Registry Number Reaxys
Last Modified
23 April 2020